Efficient synthesis of the corticosteroid side-chain from 17-ketones

Derek H.R. Barton; William B. Motherwell; Samir Z. Zard

doi:10.1039/c39810000774

Efficient synthesis of the corticosteroid side-chain from 17-ketones

Derek H.R. Barton
, William B. Motherwell
, Samir Z. Zard

Institut de Chimie des Substances Naturelles

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

Original language	English
Pages (from-to)	774-775
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/c39810000774
Publication status	Published - 1 Jan 1981
Externally published	Yes

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title = "Efficient synthesis of the corticosteroid side-chain from 17-ketones",

abstract = "Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.",

author = "Barton, \{Derek H.R.\} and Motherwell, \{William B.\} and Zard, \{Samir Z.\}",

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N2 - Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

AB - Steroidal 17-ketones react smoothly with diethyl α-isocyanoethyl phosphorate to give, after suitable oxidative and hydrolytic reactions, the dihydroxy-acetone side-chain of corticosteroids in high yield.

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JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

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ER -

Efficient synthesis of the corticosteroid side-chain from 17-ketones

Abstract

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