Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides**

Linhua Shen; Olivier Monasson; Elisa Peroni; Franck Le Bideau; Samir Messaoudi

doi:10.1002/anie.202315748

Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides**

Linhua Shen
, Olivier Monasson
, Elisa Peroni
, Franck Le Bideau
, Samir Messaoudi

Research output: Contribution to journal › Article › peer-review

Abstract

Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides.

Original language	English
Article number	e202315748
Journal	Angewandte Chemie - International Edition
Volume	62
Issue number	50
DOIs	https://doi.org/10.1002/anie.202315748
Publication status	Published - 11 Dec 2023
Externally published	Yes

Keywords

Cyclic Peptides
Electrochemistry
Nickel
Peptides
S-Arylated Cysteine

Access to Document

10.1002/anie.202315748

Cite this

@article{f2a6de4e2eb14dcabae7d1b1c3233638,

title = "Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides**",

abstract = "Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides.",

keywords = "Cyclic Peptides, Electrochemistry, Nickel, Peptides, S-Arylated Cysteine",

author = "Linhua Shen and Olivier Monasson and Elisa Peroni and \{Le Bideau\}, Franck and Samir Messaoudi",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.",

year = "2023",

month = dec,

day = "11",

doi = "10.1002/anie.202315748",

language = "English",

volume = "62",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

number = "50",

}

TY - JOUR

T1 - Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides**

AU - Shen, Linhua

AU - Monasson, Olivier

AU - Peroni, Elisa

AU - Le Bideau, Franck

AU - Messaoudi, Samir

PY - 2023/12/11

Y1 - 2023/12/11

N2 - Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides.

AB - Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides.

KW - Cyclic Peptides

KW - Electrochemistry

KW - Nickel

KW - Peptides

KW - S-Arylated Cysteine

U2 - 10.1002/anie.202315748

DO - 10.1002/anie.202315748

M3 - Article

C2 - 37906608

AN - SCOPUS:85176315506

SN - 1433-7851

VL - 62

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 50

M1 - e202315748

ER -

Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides**

Abstract

Keywords

Access to Document

Fingerprint

Cite this