Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

Guillaume Giraud Collet; Nicola Festuccia; Pablo Navarro

doi:10.1016/j.xgen.2025.100919

Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

Guillaume Giraud Collet
, Nicola Festuccia
, Pablo Navarro

Institut Pasteur
Laboratoire de Probabilités et Modèles Aléatoires

Research output: Contribution to journal › Comment/debate

Abstract

Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.¹ studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

Original language	English
Article number	100919
Journal	Cell Genomics
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/j.xgen.2025.100919
Publication status	Published - 11 Jun 2025
Externally published	Yes

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10.1016/j.xgen.2025.100919

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title = "Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path",

abstract = "Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.1 studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.",

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T2 - From diverse first transcriptional impressions to a common developmental path

AU - Giraud Collet, Guillaume

AU - Festuccia, Nicola

AU - Navarro, Pablo

PY - 2025/6/11

Y1 - 2025/6/11

N2 - Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.1 studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

AB - Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al.1 studied RNA Pol II in bovine embryos and discovered super RNA Pol II domains, a regulatory architecture promoting transcription in species with delayed ZGA.

UR - https://www.scopus.com/pages/publications/105007444290

U2 - 10.1016/j.xgen.2025.100919

DO - 10.1016/j.xgen.2025.100919

M3 - Comment/debate

AN - SCOPUS:105007444290

SN - 2666-979X

VL - 5

JO - Cell Genomics

JF - Cell Genomics

IS - 6

M1 - 100919

ER -

Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path

Abstract

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