Abstract
The mammalian brain is a tube filled by cerebrospinal fluid, which is mainly secreted by the choroid plexus and plays major roles in brain development, homeostasis, and repair. Polarized multiciliated ependymal cells line the ventricular cavities of the brain. Bundles of motile cilia protrude into the ventricles where their coordinated beating is required for normal cerebrospinal fluid outflow. Recent advances in the understanding of the mechanisms underlying the development of ependymal cells are reviewed, and their known functions under normal and pathological conditions are also discussed.
| Original language | English |
|---|---|
| Title of host publication | Patterning and Cell Type Specification in the Developing CNS and PNS |
| Subtitle of host publication | Comprehensive Developmental Neuroscience, Second Edition |
| Publisher | Elsevier |
| Pages | 1021-1036 |
| Number of pages | 16 |
| ISBN (Electronic) | 9780128144053 |
| ISBN (Print) | 9780128144060 |
| DOIs | |
| Publication status | Published - 1 Jan 2020 |
Keywords
- Brain ventricles
- Cerebrospinal fluid
- Cilia
- Ciliary beating
- Fluid flow
- Growth factors
- Hydrocephalus
- Morphogens
- Neural stem cells
- Neurogenesis