ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Alexis Gautreau; Daniel Louvard; Monique Arpin

doi:10.1016/S0955-0674(01)00300-3

ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Alexis Gautreau
, Daniel Louvard
, Monique Arpin

Institut Curie

Research output: Contribution to journal › Review article › peer-review

Abstract

The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.

Original language	English
Pages (from-to)	104-109
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0955-0674(01)00300-3
Publication status	Published - 1 Feb 2002
Externally published	Yes

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title = "ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling",

abstract = "The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.",

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AB - The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.

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DO - 10.1016/S0955-0674(01)00300-3

M3 - Review article

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ERM proteins and NF2 tumor suppressor: The Yin and Yang of cortical actin organization and cell growth signaling

Abstract

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