Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier

Emmanuelle Schmitt; Marie Naveau; Yves Mechulam

doi:10.1016/j.febslet.2009.11.002

Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier

Institut Polytechnique de Paris

Research output: Contribution to journal › Review article › peer-review

Abstract

Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

Original language	English
Pages (from-to)	405-412
Number of pages	8
Journal	FEBS Letters
Volume	584
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2009.11.002
Publication status	Published - 21 Jan 2010

Keywords

G protein
Initiator tRNA
Translation initiation

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10.1016/j.febslet.2009.11.002

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title = "Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier",

abstract = "Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.",

keywords = "G protein, Initiator tRNA, Translation initiation",

author = "Emmanuelle Schmitt and Marie Naveau and Yves Mechulam",

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AU - Schmitt, Emmanuelle

AU - Naveau, Marie

AU - Mechulam, Yves

PY - 2010/1/21

Y1 - 2010/1/21

N2 - Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

AB - Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

KW - G protein

KW - Initiator tRNA

KW - Translation initiation

U2 - 10.1016/j.febslet.2009.11.002

DO - 10.1016/j.febslet.2009.11.002

M3 - Review article

C2 - 19896944

AN - SCOPUS:71849102917

SN - 0014-5793

VL - 584

SP - 405

EP - 412

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier

Abstract

Keywords

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