Euryarchaeal genomes are folded into SMC-dependent loops and domains, but lack transcription-mediated compartmentalization

Charlotte Cockram; Agnès Thierry; Aurore Gorlas; Roxane Lestini; Romain Koszul

doi:10.1016/j.molcel.2020.12.013

Euryarchaeal genomes are folded into SMC-dependent loops and domains, but lack transcription-mediated compartmentalization

Charlotte Cockram
, Agnès Thierry
, Aurore Gorlas
, Roxane Lestini
, Romain Koszul

Research output: Contribution to journal › Article › peer-review

Abstract

Cockram et al. generate high-resolution contact maps of bacterial and euryarchaeal genomes. The H. volcanii genome contains multiple large chromatin loops and self-interacting domains similar to bacteria and eukaryotes. These structures are regulated by transcription and SMC condensin. In contrast to crenarchaea, these genomes are not organized into active/inactive compartments.

Original language	English
Pages (from-to)	459-472.e10
Journal	Molecular Cell
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.12.013
Publication status	Published - 4 Feb 2021

Keywords

DNA loops
Hi-C
SMC
archaea
bacteria
chromosome organization
compartments
euryarchaeota
high-resolution
transcription

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10.1016/j.molcel.2020.12.013

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title = "Euryarchaeal genomes are folded into SMC-dependent loops and domains, but lack transcription-mediated compartmentalization",

abstract = "Cockram et al. generate high-resolution contact maps of bacterial and euryarchaeal genomes. The H. volcanii genome contains multiple large chromatin loops and self-interacting domains similar to bacteria and eukaryotes. These structures are regulated by transcription and SMC condensin. In contrast to crenarchaea, these genomes are not organized into active/inactive compartments.",

keywords = "DNA loops, Hi-C, SMC, archaea, bacteria, chromosome organization, compartments, euryarchaeota, high-resolution, transcription",

author = "Charlotte Cockram and Agn{\`e}s Thierry and Aurore Gorlas and Roxane Lestini and Romain Koszul",

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AU - Cockram, Charlotte

AU - Thierry, Agnès

AU - Gorlas, Aurore

AU - Lestini, Roxane

AU - Koszul, Romain

PY - 2021/2/4

Y1 - 2021/2/4

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AB - Cockram et al. generate high-resolution contact maps of bacterial and euryarchaeal genomes. The H. volcanii genome contains multiple large chromatin loops and self-interacting domains similar to bacteria and eukaryotes. These structures are regulated by transcription and SMC condensin. In contrast to crenarchaea, these genomes are not organized into active/inactive compartments.

KW - DNA loops

KW - Hi-C

KW - SMC

KW - archaea

KW - bacteria

KW - chromosome organization

KW - compartments

KW - euryarchaeota

KW - high-resolution

KW - transcription

U2 - 10.1016/j.molcel.2020.12.013

DO - 10.1016/j.molcel.2020.12.013

M3 - Article

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VL - 81

SP - 459-472.e10

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

Euryarchaeal genomes are folded into SMC-dependent loops and domains, but lack transcription-mediated compartmentalization

Abstract

Keywords

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