Exclusive platination of loop adenines in the human telomeric G-quadruplex

Hélène Bertrand; Sophie Bombard; David Monchaud; Eric Talbot; Aurore Guédin; Jean Louis Mergny; Renate Grünert; Patrick J. Bednarski; Marie Paule Teulade-Fichou

doi:10.1039/b904599f

Exclusive platination of loop adenines in the human telomeric G-quadruplex

Hélène Bertrand
, Sophie Bombard
, David Monchaud
, Eric Talbot
, Aurore Guédin
, Jean Louis Mergny
, Renate Grünert
, Patrick J. Bednarski
, Marie Paule Teulade-Fichou

Institut Curie
Université Paris Descartes
CNRS/Museum National d'Histoire Naturelle/IRD/UPMC
University of Greifswald

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

The present article reports on the platination of the human telomeric G-quadruplex by three Pt-terpyridine complexes. It is shown that extension of the aromatic surface of the terpyridine moiety surrounding the platinum atom influences both the binding affinity and the platination activity. Remarkably, the most strongly bound complex Pt-ttpy coordinates exclusively the adenine nucleobases present in the loop of the G-quadruplex. This exclusive single-site platination reflects the interaction of the compound with both the G-tetrad and the loop residues. In addition Pt-ttpy showed promising antiproliferative activity on a panel of cancer cell lines in a parallel study using cisplatin derivatives currently in clinical use.

Original language	English
Pages (from-to)	2864-2871
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	7
Issue number	14
DOIs	https://doi.org/10.1039/b904599f
Publication status	Published - 20 Jul 2009
Externally published	Yes

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abstract = "The present article reports on the platination of the human telomeric G-quadruplex by three Pt-terpyridine complexes. It is shown that extension of the aromatic surface of the terpyridine moiety surrounding the platinum atom influences both the binding affinity and the platination activity. Remarkably, the most strongly bound complex Pt-ttpy coordinates exclusively the adenine nucleobases present in the loop of the G-quadruplex. This exclusive single-site platination reflects the interaction of the compound with both the G-tetrad and the loop residues. In addition Pt-ttpy showed promising antiproliferative activity on a panel of cancer cell lines in a parallel study using cisplatin derivatives currently in clinical use.",

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AU - Bertrand, Hélène

AU - Bombard, Sophie

AU - Monchaud, David

AU - Talbot, Eric

AU - Guédin, Aurore

AU - Mergny, Jean Louis

AU - Grünert, Renate

AU - Bednarski, Patrick J.

AU - Teulade-Fichou, Marie Paule

PY - 2009/7/20

Y1 - 2009/7/20

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AB - The present article reports on the platination of the human telomeric G-quadruplex by three Pt-terpyridine complexes. It is shown that extension of the aromatic surface of the terpyridine moiety surrounding the platinum atom influences both the binding affinity and the platination activity. Remarkably, the most strongly bound complex Pt-ttpy coordinates exclusively the adenine nucleobases present in the loop of the G-quadruplex. This exclusive single-site platination reflects the interaction of the compound with both the G-tetrad and the loop residues. In addition Pt-ttpy showed promising antiproliferative activity on a panel of cancer cell lines in a parallel study using cisplatin derivatives currently in clinical use.

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DO - 10.1039/b904599f

M3 - Article

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AN - SCOPUS:67650439449

SN - 1477-0520

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SP - 2864

EP - 2871

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 14

ER -

Exclusive platination of loop adenines in the human telomeric G-quadruplex

Abstract

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