Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil; Christiane Moog; Stéphan Vagner; Nadia Benkirane-Jessel; Duncan R. Smith; Laurent Désaubry

doi:10.1016/j.ejmech.2020.112653

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil, Christiane Moog, Stéphan Vagner, Nadia Benkirane-Jessel, Duncan R. Smith, Laurent Désaubry

Research output: Contribution to journal › Article › peer-review

Abstract

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Original language	English
Article number	112653
Journal	European Journal of Medicinal Chemistry
Volume	203
DOIs	https://doi.org/10.1016/j.ejmech.2020.112653
Publication status	Published - 1 Oct 2020
Externally published	Yes

Keywords

COVID-19
Chikungunya virus
Coronavirus
Ebola virus
Natural products
Picornaviruses
Prohibitin
SARS-CoV-2
Zika virus
eIF4A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejmech.2020.112653

Cite this

@article{5f7bbb545170409993be9e765df21089,

title = "Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses",

abstract = "Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).",

keywords = "COVID-19, Chikungunya virus, Coronavirus, Ebola virus, Natural products, Picornaviruses, Prohibitin, SARS-CoV-2, Zika virus, eIF4A",

author = "Nebigil, \{Canan G.\} and Christiane Moog and St{\'e}phan Vagner and Nadia Benkirane-Jessel and Smith, \{Duncan R.\} and Laurent D{\'e}saubry",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Masson SAS",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.ejmech.2020.112653",

language = "English",

volume = "203",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

}

TY - JOUR

T1 - Flavaglines as natural products targeting eIF4A and prohibitins

T2 - From traditional Chinese medicine to antiviral activity against coronaviruses

AU - Nebigil, Canan G.

AU - Moog, Christiane

AU - Vagner, Stéphan

AU - Benkirane-Jessel, Nadia

AU - Smith, Duncan R.

AU - Désaubry, Laurent

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

AB - Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

KW - COVID-19

KW - Chikungunya virus

KW - Coronavirus

KW - Ebola virus

KW - Natural products

KW - Picornaviruses

KW - Prohibitin

KW - SARS-CoV-2

KW - Zika virus

KW - eIF4A

U2 - 10.1016/j.ejmech.2020.112653

DO - 10.1016/j.ejmech.2020.112653

M3 - Article

C2 - 32693294

AN - SCOPUS:85088007294

SN - 0223-5234

VL - 203

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 112653

ER -

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this