Functionalization of DNA G-Wires for patterning and nanofabrication

Sébastien Lyonnais; Olivier Piétrement; Alexei Chepelianski; Sophie Guéron; Laurent Lacroix; Eric Le Cam; Jean Louis Mergny

doi:10.1093/nass/nrn348

Functionalization of DNA G-Wires for patterning and nanofabrication

Sébastien Lyonnais
, Olivier Piétrement
, Alexei Chepelianski
, Sophie Guéron
, Laurent Lacroix
, Eric Le Cam
, Jean Louis Mergny

CNRS/Museum National d'Histoire Naturelle/IRD/UPMC

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

DNA structures made of guanine tetrads present remarkable properties and are thus first choice candidates for applications in nanofabrication. Starting from the work of Kotlyar et al., we report here that the klenow exo(-) fragment of DNA polymerase I can extend poly(dG)-poly(dC) from various 5'-modified (dG)(10(-))(dC)(10) templates. This allows the production of end-functionalized four-stranded wires (G-Wires) assembled from the folding of poly(dG) strands. G-Wires bearing thiol moieties can be easily combed on Au and Pt surfaces, whereas a 5' single-stranded overhang of a random sequence provides the unique possibility to assemble complex structures for nanoconstruction purposes.

Original language	English
Pages (from-to)	689-690
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	52
DOIs	https://doi.org/10.1093/nass/nrn348
Publication status	Published - 1 Jan 2008
Externally published	Yes

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title = "Functionalization of DNA G-Wires for patterning and nanofabrication",

abstract = "DNA structures made of guanine tetrads present remarkable properties and are thus first choice candidates for applications in nanofabrication. Starting from the work of Kotlyar et al., we report here that the klenow exo(-) fragment of DNA polymerase I can extend poly(dG)-poly(dC) from various 5'-modified (dG)(10(-))(dC)(10) templates. This allows the production of end-functionalized four-stranded wires (G-Wires) assembled from the folding of poly(dG) strands. G-Wires bearing thiol moieties can be easily combed on Au and Pt surfaces, whereas a 5' single-stranded overhang of a random sequence provides the unique possibility to assemble complex structures for nanoconstruction purposes.",

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T1 - Functionalization of DNA G-Wires for patterning and nanofabrication

AU - Lyonnais, Sébastien

AU - Piétrement, Olivier

AU - Chepelianski, Alexei

AU - Guéron, Sophie

AU - Lacroix, Laurent

AU - Le Cam, Eric

AU - Mergny, Jean Louis

PY - 2008/1/1

Y1 - 2008/1/1

N2 - DNA structures made of guanine tetrads present remarkable properties and are thus first choice candidates for applications in nanofabrication. Starting from the work of Kotlyar et al., we report here that the klenow exo(-) fragment of DNA polymerase I can extend poly(dG)-poly(dC) from various 5'-modified (dG)(10(-))(dC)(10) templates. This allows the production of end-functionalized four-stranded wires (G-Wires) assembled from the folding of poly(dG) strands. G-Wires bearing thiol moieties can be easily combed on Au and Pt surfaces, whereas a 5' single-stranded overhang of a random sequence provides the unique possibility to assemble complex structures for nanoconstruction purposes.

AB - DNA structures made of guanine tetrads present remarkable properties and are thus first choice candidates for applications in nanofabrication. Starting from the work of Kotlyar et al., we report here that the klenow exo(-) fragment of DNA polymerase I can extend poly(dG)-poly(dC) from various 5'-modified (dG)(10(-))(dC)(10) templates. This allows the production of end-functionalized four-stranded wires (G-Wires) assembled from the folding of poly(dG) strands. G-Wires bearing thiol moieties can be easily combed on Au and Pt surfaces, whereas a 5' single-stranded overhang of a random sequence provides the unique possibility to assemble complex structures for nanoconstruction purposes.

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DO - 10.1093/nass/nrn348

M3 - Article

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AN - SCOPUS:78649431053

SN - 1746-8272

SP - 689

EP - 690

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 52

ER -

Functionalization of DNA G-Wires for patterning and nanofabrication

Abstract

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