Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

E. Beaurepaire; D. Giaume; V. Buissette; M. P. Sauviat; D. Casanova; E. Auksorius; J. L. Martin; K. Lahlil; T. Gacoin; J. P. Boilot; A. Alexandrou

doi:10.1117/12.590737

Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

E. Beaurepaire, D. Giaume, V. Buissette, M. P. Sauviat, D. Casanova, E. Auksorius, J. L. Martin, K. Lahlil, T. Gacoin, J. P. Boilot, A. Alexandrou

Institut Polytechnique de Paris

Research output: Contribution to journal › Conference article › peer-review

Abstract

Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.

Original language	English
Article number	46
Pages (from-to)	192-198
Number of pages	7
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5705
DOIs	https://doi.org/10.1117/12.590737
Publication status	Published - 16 Aug 2005
Event	Nanobiophotonics and Biomedical Applications II - San Jose, CA, United States Duration: 24 Jan 2005 → 27 Jan 2005

Keywords

Lanthanide
Nanoparticles
Single molecule tracking

Access to Document

10.1117/12.590737

Cite this

Beaurepaire, E., Giaume, D., Buissette, V., Sauviat, M. P., Casanova, D., Auksorius, E., Martin, J. L., Lahlil, K., Gacoin, T., Boilot, J. P., & Alexandrou, A. (2005). Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5705, 192-198. Article 46. https://doi.org/10.1117/12.590737

@article{82e38ca2732b488c84d77fe512d861c2,

title = "Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level",

abstract = "Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.",

keywords = "Lanthanide, Nanoparticles, Single molecule tracking",

author = "E. Beaurepaire and D. Giaume and V. Buissette and Sauviat, \{M. P.\} and D. Casanova and E. Auksorius and Martin, \{J. L.\} and K. Lahlil and T. Gacoin and Boilot, \{J. P.\} and A. Alexandrou",

year = "2005",

month = aug,

day = "16",

doi = "10.1117/12.590737",

language = "English",

volume = "5705",

pages = "192--198",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

issn = "1605-7422",

note = "Nanobiophotonics and Biomedical Applications II ; Conference date: 24-01-2005 Through 27-01-2005",

}

Beaurepaire, E, Giaume, D, Buissette, V, Sauviat, MP, Casanova, D, Auksorius, E, Martin, JL, Lahlil, K , Gacoin, T, Boilot, JP & Alexandrou, A 2005, 'Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level', Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 5705, 46, pp. 192-198. https://doi.org/10.1117/12.590737

TY - JOUR

T1 - Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

AU - Beaurepaire, E.

AU - Giaume, D.

AU - Buissette, V.

AU - Sauviat, M. P.

AU - Casanova, D.

AU - Auksorius, E.

AU - Martin, J. L.

AU - Lahlil, K.

AU - Gacoin, T.

AU - Boilot, J. P.

AU - Alexandrou, A.

PY - 2005/8/16

Y1 - 2005/8/16

N2 - Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.

AB - Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.

KW - Lanthanide

KW - Nanoparticles

KW - Single molecule tracking

U2 - 10.1117/12.590737

DO - 10.1117/12.590737

M3 - Conference article

AN - SCOPUS:23244436719

SN - 1605-7422

VL - 5705

SP - 192

EP - 198

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 46

T2 - Nanobiophotonics and Biomedical Applications II

Y2 - 24 January 2005 through 27 January 2005

ER -

Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level

Abstract

Keywords

Access to Document

Fingerprint

Cite this