Genetic manipulation of insulin action and β-cell function in mice

Betty Lamothe; Bertrand Duvillié; Nathalie Cordonnier; Anne Baudry; Susan Saint-Just; Danielle Bucchini; Jacques Jami; Rajiv L. Joshi

doi:10.1023/A:1006813712567

Genetic manipulation of insulin action and β-cell function in mice

Betty Lamothe
, Bertrand Duvillié
, Nathalie Cordonnier
, Anne Baudry
, Susan Saint-Just
, Danielle Bucchini
, Jacques Jami
, Rajiv L. Joshi

Institut Cochin
INSERM U869

Research output: Contribution to journal › Article › peer-review

Abstract

Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	Molecular and Cellular Biochemistry
Volume	182
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1006813712567
Publication status	Published - 5 May 1998
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animal models
Knockout mice
NIDDM
Transgenic mice

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10.1023/A:1006813712567

Cite this

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AU - Lamothe, Betty

AU - Duvillié, Bertrand

AU - Cordonnier, Nathalie

AU - Baudry, Anne

AU - Saint-Just, Susan

AU - Bucchini, Danielle

AU - Jami, Jacques

AU - Joshi, Rajiv L.

PY - 1998/5/5

Y1 - 1998/5/5

N2 - Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

AB - Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such mutant mice will allow in the future to develop animal models in which the pathophysiologies resulting from polygenic defects might be reconstituted and studied in detail. Such animal models hopefully will lead to better understanding of complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM).

KW - Animal models

KW - Knockout mice

KW - NIDDM

KW - Transgenic mice

U2 - 10.1023/A:1006813712567

DO - 10.1023/A:1006813712567

M3 - Article

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EP - 168

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 1-2

ER -

Genetic manipulation of insulin action and β-cell function in mice

Abstract

UN SDGs

Keywords

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