Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors

Didier Monté; Laurent Coutte; Frédérique Dewitte; Pierre Antoine Defossez; Maryvonne Le Coniat; Dominique Stéhelin; Roland Berger; Yvan De Launoit

doi:10.1006/geno.1996.0345

Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors

Didier Monté
, Laurent Coutte
, Frédérique Dewitte
, Pierre Antoine Defossez
, Maryvonne Le Coniat
, Dominique Stéhelin
, Roland Berger
, Yvan De Launoit

Institut Pasteur de Lille
INSERM U869

Research output: Contribution to journal › Article › peer-review

Abstract

The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3.

Original language	English
Pages (from-to)	236-240
Number of pages	5
Journal	Genomics
Volume	35
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0345
Publication status	Published - 1 Jul 1996
Externally published	Yes

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title = "Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors",

abstract = "The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3.",

author = "Didier Mont{\'e} and Laurent Coutte and Fr{\'e}d{\'e}rique Dewitte and Defossez, \{Pierre Antoine\} and \{Le Coniat\}, Maryvonne and Dominique St{\'e}helin and Roland Berger and \{De Launoit\}, Yvan",

year = "1996",

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doi = "10.1006/geno.1996.0345",

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AU - Monté, Didier

AU - Coutte, Laurent

AU - Dewitte, Frédérique

AU - Defossez, Pierre Antoine

AU - Le Coniat, Maryvonne

AU - Stéhelin, Dominique

AU - Berger, Roland

AU - De Launoit, Yvan

PY - 1996/7/1

Y1 - 1996/7/1

N2 - The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3.

AB - The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3.

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DO - 10.1006/geno.1996.0345

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SP - 236

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JO - Genomics

JF - Genomics

IS - 1

ER -

Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors

Abstract

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