Globule to helix transition in sodiated polyalanines

Jonathan K. Martens; Isabelle Compagnon; Edith Nicol; Terry B. McMahon; Carine Clavaguéra; Gilles Ohanessian

doi:10.1021/jz301326w

Globule to helix transition in sodiated polyalanines

Jonathan K. Martens
, Isabelle Compagnon
, Edith Nicol
, Terry B. McMahon
, Carine Clavaguéra
, Gilles Ohanessian

CNRS
Department of Chemistry
University of Waterloo
University of Lyon
IGFL, Université de Lyon, Université Lyon 1
Centre national de la recherche scientifique

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The structures of sodiated polyalanine peptides containing 8-12 residues are investigated using infrared multiple photon dissociation (IRMPD) spectroscopy and classical and quantum modeling. Calculations indicate that the α-helical structure is the most stable conformation for the peptides whatever their size. The IRMPD spectra provide evidence for the coexistence of helical and globular shapes for Ala₈Na⁺, and possibly for Ala₉Na⁺. The turning point from globule to helix is thus found at Ala_8-9Na⁺. The N-H and O-H stretching region allows identifying a new spectroscopic pattern typical for α-helical structures of polyalanines.

Original language	English
Pages (from-to)	3320-3324
Number of pages	5
Journal	Journal of Physical Chemistry Letters
Volume	3
Issue number	22
DOIs	https://doi.org/10.1021/jz301326w
Publication status	Published - 15 Nov 2012
Externally published	Yes

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title = "Globule to helix transition in sodiated polyalanines",

abstract = "The structures of sodiated polyalanine peptides containing 8-12 residues are investigated using infrared multiple photon dissociation (IRMPD) spectroscopy and classical and quantum modeling. Calculations indicate that the α-helical structure is the most stable conformation for the peptides whatever their size. The IRMPD spectra provide evidence for the coexistence of helical and globular shapes for Ala8Na+, and possibly for Ala9Na+. The turning point from globule to helix is thus found at Ala8-9Na+. The N-H and O-H stretching region allows identifying a new spectroscopic pattern typical for α-helical structures of polyalanines.",

author = "Martens, \{Jonathan K.\} and Isabelle Compagnon and Edith Nicol and McMahon, \{Terry B.\} and Carine Clavagu{\'e}ra and Gilles Ohanessian",

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TY - JOUR

T1 - Globule to helix transition in sodiated polyalanines

AU - Martens, Jonathan K.

AU - Compagnon, Isabelle

AU - Nicol, Edith

AU - McMahon, Terry B.

AU - Clavaguéra, Carine

AU - Ohanessian, Gilles

PY - 2012/11/15

Y1 - 2012/11/15

N2 - The structures of sodiated polyalanine peptides containing 8-12 residues are investigated using infrared multiple photon dissociation (IRMPD) spectroscopy and classical and quantum modeling. Calculations indicate that the α-helical structure is the most stable conformation for the peptides whatever their size. The IRMPD spectra provide evidence for the coexistence of helical and globular shapes for Ala8Na+, and possibly for Ala9Na+. The turning point from globule to helix is thus found at Ala8-9Na+. The N-H and O-H stretching region allows identifying a new spectroscopic pattern typical for α-helical structures of polyalanines.

AB - The structures of sodiated polyalanine peptides containing 8-12 residues are investigated using infrared multiple photon dissociation (IRMPD) spectroscopy and classical and quantum modeling. Calculations indicate that the α-helical structure is the most stable conformation for the peptides whatever their size. The IRMPD spectra provide evidence for the coexistence of helical and globular shapes for Ala8Na+, and possibly for Ala9Na+. The turning point from globule to helix is thus found at Ala8-9Na+. The N-H and O-H stretching region allows identifying a new spectroscopic pattern typical for α-helical structures of polyalanines.

U2 - 10.1021/jz301326w

DO - 10.1021/jz301326w

M3 - Article

AN - SCOPUS:84869476244

SN - 1948-7185

VL - 3

SP - 3320

EP - 3324

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

IS - 22

ER -

Globule to helix transition in sodiated polyalanines

Abstract

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