Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Stéphane Duigou; Kristine G. Knudsen; Ole Skovgaard; Elizabeth S. Egan; Anders Løbner-Olesen; Matthew K. Waldor

doi:10.1128/JB.00565-06

Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Stéphane Duigou
, Kristine G. Knudsen
, Ole Skovgaard
, Elizabeth S. Egan
, Anders Løbner-Olesen
, Matthew K. Waldor

Research output: Contribution to journal › Article › peer-review

Abstract

Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

Original language	English
Pages (from-to)	6419-6424
Number of pages	6
Journal	Journal of Bacteriology
Volume	188
Issue number	17
DOIs	https://doi.org/10.1128/JB.00565-06
Publication status	Published - 1 Sept 2006
Externally published	Yes

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title = "Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB",

abstract = "Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.",

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AU - Duigou, Stéphane

AU - Knudsen, Kristine G.

AU - Skovgaard, Ole

AU - Egan, Elizabeth S.

AU - Løbner-Olesen, Anders

AU - Waldor, Matthew K.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

AB - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

UR - https://www.scopus.com/pages/publications/33749031561

U2 - 10.1128/JB.00565-06

DO - 10.1128/JB.00565-06

M3 - Article

C2 - 16923911

AN - SCOPUS:33749031561

SN - 0021-9193

VL - 188

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EP - 6424

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 17

ER -

Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Abstract

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