Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

Raphaël F.X. Tomasi; Sébastien Sart; Tiphaine Champetier; Charles N. Baroud

doi:10.1016/j.celrep.2020.107670

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

Raphaël F.X. Tomasi
, Sébastien Sart
, Tiphaine Champetier
, Charles N. Baroud

Research output: Contribution to journal › Article › peer-review

Abstract

Tomasi et al. describe a microfluidic droplet approach to sequentially modulate culture conditions on 3D spheroids, enabling complex protocols such as co-culture, hydrogel encapsulation, or drug testing. When applied to a drug toxicity experiment on a chip, the platform yields time-resolved, single-cell data that uncover a dynamic response regulated at the spheroid level.

Original language	English
Article number	107670
Journal	Cell Reports
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.107670
Publication status	Published - 26 May 2020

Keywords

droplet microfluidics
liver toxicity
organoids
spheroids
tissue engineering

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10.1016/j.celrep.2020.107670

Cite this

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abstract = "Tomasi et al. describe a microfluidic droplet approach to sequentially modulate culture conditions on 3D spheroids, enabling complex protocols such as co-culture, hydrogel encapsulation, or drug testing. When applied to a drug toxicity experiment on a chip, the platform yields time-resolved, single-cell data that uncover a dynamic response regulated at the spheroid level.",

keywords = "droplet microfluidics, liver toxicity, organoids, spheroids, tissue engineering",

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AU - Tomasi, Raphaël F.X.

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AU - Champetier, Tiphaine

AU - Baroud, Charles N.

PY - 2020/5/26

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N2 - Tomasi et al. describe a microfluidic droplet approach to sequentially modulate culture conditions on 3D spheroids, enabling complex protocols such as co-culture, hydrogel encapsulation, or drug testing. When applied to a drug toxicity experiment on a chip, the platform yields time-resolved, single-cell data that uncover a dynamic response regulated at the spheroid level.

AB - Tomasi et al. describe a microfluidic droplet approach to sequentially modulate culture conditions on 3D spheroids, enabling complex protocols such as co-culture, hydrogel encapsulation, or drug testing. When applied to a drug toxicity experiment on a chip, the platform yields time-resolved, single-cell data that uncover a dynamic response regulated at the spheroid level.

KW - droplet microfluidics

KW - liver toxicity

KW - organoids

KW - spheroids

KW - tissue engineering

UR - https://www.scopus.com/pages/publications/85085278977

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DO - 10.1016/j.celrep.2020.107670

M3 - Article

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Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

Abstract

Keywords

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