Inference of Hopfield-Potts patterns from covariation in protein families: Calculation and statistical error bars

Simona Cocco; Rémi Monasson; Martin Weigt

doi:10.1088/1742-6596/473/1/012010

Inference of Hopfield-Potts patterns from covariation in protein families: Calculation and statistical error bars

Simona Cocco
, Rémi Monasson
, Martin Weigt

École Polytechnique

Research output: Contribution to journal › Conference article › peer-review

Abstract

We consider the Hopfield-Potts model for the covariation between residues in protein families recently introduced in Cocco, Monasson, Weigt (2013). The patterns of the model are inferred from the data within a new gauge, more symmetric in the residues. We compute the statistical error bars on the pattern components. Results are illustrated on real data for a response regulator receiver domain (Pfam ID PF00072) family.

Original language	English
Article number	012010
Journal	Journal of Physics: Conference Series
Volume	473
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/473/1/012010
Publication status	Published - 1 Jan 2013
Event	ELC International Meeting on Inference, Computation, and Spin Glasses, ICSG 2013 - Sapporo, Japan Duration: 28 Jul 2013 → 30 Jul 2013

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10.1088/1742-6596/473/1/012010

Cite this

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title = "Inference of Hopfield-Potts patterns from covariation in protein families: Calculation and statistical error bars",

abstract = "We consider the Hopfield-Potts model for the covariation between residues in protein families recently introduced in Cocco, Monasson, Weigt (2013). The patterns of the model are inferred from the data within a new gauge, more symmetric in the residues. We compute the statistical error bars on the pattern components. Results are illustrated on real data for a response regulator receiver domain (Pfam ID PF00072) family.",

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T2 - ELC International Meeting on Inference, Computation, and Spin Glasses, ICSG 2013

AU - Cocco, Simona

AU - Monasson, Rémi

AU - Weigt, Martin

PY - 2013/1/1

Y1 - 2013/1/1

N2 - We consider the Hopfield-Potts model for the covariation between residues in protein families recently introduced in Cocco, Monasson, Weigt (2013). The patterns of the model are inferred from the data within a new gauge, more symmetric in the residues. We compute the statistical error bars on the pattern components. Results are illustrated on real data for a response regulator receiver domain (Pfam ID PF00072) family.

AB - We consider the Hopfield-Potts model for the covariation between residues in protein families recently introduced in Cocco, Monasson, Weigt (2013). The patterns of the model are inferred from the data within a new gauge, more symmetric in the residues. We compute the statistical error bars on the pattern components. Results are illustrated on real data for a response regulator receiver domain (Pfam ID PF00072) family.

U2 - 10.1088/1742-6596/473/1/012010

DO - 10.1088/1742-6596/473/1/012010

M3 - Conference article

AN - SCOPUS:84891809621

SN - 1742-6588

VL - 473

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

IS - 1

M1 - 012010

Y2 - 28 July 2013 through 30 July 2013

ER -

Inference of Hopfield-Potts patterns from covariation in protein families: Calculation and statistical error bars

Abstract

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