Abstract
Incorporation of Cu(OAc)2 as oxidant in Ni/AcOH-promoted 5-endo radical cyclisations of N-alkenyl-trichloroacetamides allows an interesting control of the oxidation level of the products, as illustrated by the conversion of 3 into either 4 or 5. In addition, allylic trichloroacetamides 13a-f under the same conditions underwent a 5-exo radical cyclisation-oxidation sequence leading to unsaturated hydroindolones, which represent valuable synthetic intermediates.
| Original language | English |
|---|---|
| Pages (from-to) | 471-474 |
| Number of pages | 4 |
| Journal | Synlett |
| Issue number | 4 |
| Publication status | Published - 1 Jan 2000 |
Keywords
- 5-endo radical cyclisation
- 5-exo radical cyclisation
- Cu(OAc)
- Nickel
- Trichloroacetamide