Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

Arvid Lindberg; Jérémy Vizet; Jean Rehbinder; Camille Gennet; Jean Charles Vanel; Angelo Pierangelo

doi:10.1117/12.2510232

Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

Arvid Lindberg
, Jérémy Vizet
, Jean Rehbinder
, Camille Gennet
, Jean Charles Vanel
, Angelo Pierangelo

Université de Strasbourg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm²) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.

Original language	English
Title of host publication	Optical Biopsy XVII
Subtitle of host publication	Toward Real-Time Spectroscopic Imaging and Diagnosis
Editors	Robert R. Alfano, Stavros G. Demos, Angela B. Seddon
Publisher	SPIE
ISBN (Electronic)	9781510623880
DOIs	https://doi.org/10.1117/12.2510232
Publication status	Published - 1 Jan 2019
Event	Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2019 - San Francisco, United States Duration: 5 Feb 2019 → 6 Feb 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10873
ISSN (Print)	1605-7422

Conference

Conference	Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2019
Country/Territory	United States
City	San Francisco
Period	5/02/19 → 6/02/19

Keywords

Depolarization
Eigenvalue Calibration Method
Ferroelectric Liquid Crystals
In vivo imaging
Mueller Matrix
Mueller Polarimetric Imaging
Multispectral Imaging
Polarization of light

Access to Document

10.1117/12.2510232

Cite this

Lindberg, A., Vizet, J., Rehbinder, J., Gennet, C., Vanel, J. C., & Pierangelo, A. (2019). Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo. In R. R. Alfano, S. G. Demos, & A. B. Seddon (Eds.), Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis Article 108730J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10873). SPIE. https://doi.org/10.1117/12.2510232

Lindberg, Arvid ; Vizet, Jérémy ; Rehbinder, Jean et al. / Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo. Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis. editor / Robert R. Alfano ; Stavros G. Demos ; Angela B. Seddon. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{e49bdb87f9fd42e18080658ade62bdf6,

title = "Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo",

abstract = "Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm2) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1\% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.",

keywords = "Depolarization, Eigenvalue Calibration Method, Ferroelectric Liquid Crystals, In vivo imaging, Mueller Matrix, Mueller Polarimetric Imaging, Multispectral Imaging, Polarization of light",

author = "Arvid Lindberg and J{\'e}r{\'e}my Vizet and Jean Rehbinder and Camille Gennet and Vanel, \{Jean Charles\} and Angelo Pierangelo",

note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2019 ; Conference date: 05-02-2019 Through 06-02-2019",

year = "2019",

month = jan,

day = "1",

doi = "10.1117/12.2510232",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Alfano, \{Robert R.\} and Demos, \{Stavros G.\} and Seddon, \{Angela B.\}",

booktitle = "Optical Biopsy XVII",

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Lindberg, A, Vizet, J, Rehbinder, J, Gennet, C, Vanel, JC & Pierangelo, A 2019, Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo. in RR Alfano, SG Demos & AB Seddon (eds), Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis., 108730J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10873, SPIE, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2019, San Francisco, United States, 5/02/19. https://doi.org/10.1117/12.2510232

Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo. / Lindberg, Arvid; Vizet, Jérémy; Rehbinder, Jean et al.
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis. ed. / Robert R. Alfano; Stavros G. Demos; Angela B. Seddon. SPIE, 2019. 108730J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10873).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

AU - Lindberg, Arvid

AU - Vizet, Jérémy

AU - Rehbinder, Jean

AU - Gennet, Camille

AU - Vanel, Jean Charles

AU - Pierangelo, Angelo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm2) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.

AB - Mueller Polarimetric Imaging (MPI) showed promising results in biomedical applications, especially for early detection of precancerous lesions on biological tissues. This technique is label-free, non-invasive and can be implemented with a large field of view (up to several cm2) to image wide areas of biological tissues while providing information on its microstructure. The development of innovative (MPI) systems, able to analyze biological tissues in vivo on human patients, remains an instrumental challenge. Our goal is to build miniaturized and compact full-field MPI systems based on Ferroelectric Liquid Crystals (FLCs) capable of performing a multispectral accurate analysis of biological tissues in vivo. In this work, an innovative approach is showed to realize optimized and fast FLCs-based MPI systems able to perform full-field imaging acquisitions in the spectral range between 450 and 700nm with error less than 1% on all the elements of measured Mueller matrices. This system can be accurately calibrated by using the Eigenvalue Calibration Method (ECM) also in presence of high residual instrumental depolarization. This approach enables us to realize compact and reliable MPI systems which can be easily integrated into existing instruments currently used in medical practice.

KW - Depolarization

KW - Eigenvalue Calibration Method

KW - Ferroelectric Liquid Crystals

KW - In vivo imaging

KW - Mueller Matrix

KW - Mueller Polarimetric Imaging

KW - Multispectral Imaging

KW - Polarization of light

U2 - 10.1117/12.2510232

DO - 10.1117/12.2510232

M3 - Conference contribution

AN - SCOPUS:85076809724

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Biopsy XVII

A2 - Alfano, Robert R.

A2 - Demos, Stavros G.

A2 - Seddon, Angela B.

PB - SPIE

T2 - Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2019

Y2 - 5 February 2019 through 6 February 2019

ER -

Lindberg A, Vizet J, Rehbinder J, Gennet C, Vanel JC, Pierangelo A. Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo. In Alfano RR, Demos SG, Seddon AB, editors, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis. SPIE. 2019. 108730J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2510232

Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo

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Keywords

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