Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli

Erick Denamur; Olivier Tenaillon; Catherine Deschamps; David Skurnik; Esthel Ronco; Jean Louis Gaillard; Bertrand Picard; Catherine Branger; Ivan Matic

doi:10.1534/genetics.105.045526

Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli

Erick Denamur
, Olivier Tenaillon
, Catherine Deschamps
, David Skurnik
, Esthel Ronco
, Jean Louis Gaillard
, Bertrand Picard
, Catherine Branger
, Ivan Matic

Research output: Contribution to journal › Article › peer-review

Abstract

In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.

Original language	English
Pages (from-to)	825-827
Number of pages	3
Journal	Genetics
Volume	171
Issue number	2
DOIs	https://doi.org/10.1534/genetics.105.045526
Publication status	Published - 1 Jan 2005
Externally published	Yes

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title = "Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli",

abstract = "In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.",

author = "Erick Denamur and Olivier Tenaillon and Catherine Deschamps and David Skurnik and Esthel Ronco and Gaillard, \{Jean Louis\} and Bertrand Picard and Catherine Branger and Ivan Matic",

year = "2005",

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doi = "10.1534/genetics.105.045526",

language = "English",

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T1 - Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli

AU - Denamur, Erick

AU - Tenaillon, Olivier

AU - Deschamps, Catherine

AU - Skurnik, David

AU - Ronco, Esthel

AU - Gaillard, Jean Louis

AU - Picard, Bertrand

AU - Branger, Catherine

AU - Matic, Ivan

PY - 2005/1/1

Y1 - 2005/1/1

N2 - In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.

AB - In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.

UR - https://www.scopus.com/pages/publications/31544468664

U2 - 10.1534/genetics.105.045526

DO - 10.1534/genetics.105.045526

M3 - Article

C2 - 15965238

AN - SCOPUS:31544468664

SN - 0016-6731

VL - 171

SP - 825

EP - 827

JO - Genetics

JF - Genetics

IS - 2

ER -

Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli

Abstract

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