Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites

Stéphan Vagner; Bruno Galy; Stéphane Pyronnet

doi:10.1093/embo-reports/kve208

Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites

Stéphan Vagner
, Bruno Galy
, Stéphane Pyronnet

Research output: Contribution to journal › Review article › peer-review

Abstract

Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

Original language	English
Pages (from-to)	893-898
Number of pages	6
Journal	EMBO Reports
Volume	2
Issue number	10
DOIs	https://doi.org/10.1093/embo-reports/kve208
Publication status	Published - 1 Jan 2001
Externally published	Yes

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10.1093/embo-reports/kve208

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title = "Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites",

abstract = "Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.",

author = "St{\'e}phan Vagner and Bruno Galy and St{\'e}phane Pyronnet",

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AU - Vagner, Stéphan

AU - Galy, Bruno

AU - Pyronnet, Stéphane

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Y1 - 2001/1/1

N2 - Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

AB - Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

UR - https://www.scopus.com/pages/publications/0034764497

U2 - 10.1093/embo-reports/kve208

DO - 10.1093/embo-reports/kve208

M3 - Review article

C2 - 11600453

AN - SCOPUS:0034764497

SN - 1469-221X

VL - 2

SP - 893

EP - 898

JO - EMBO Reports

JF - EMBO Reports

IS - 10

ER -

Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites

Abstract

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