TY - JOUR
T1 - Isocombretastatins A versus combretastatins A
T2 - The forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent
AU - Messaoudi, Samir
AU - Tréguier, Bret
AU - Hamze, Abdallah
AU - Provot, Olivier
AU - Peyrat, Jean François
AU - De Losada, Jordi Rodrigo
AU - Liu, Jian Miao
AU - Bignon, Jérôme
AU - Wdzieczak-Bakala, Joanna
AU - Thoret, Sylviane
AU - Dubois, Joelle
AU - Brion, Jean Daniel
AU - Alami, Mouâd
PY - 2009/7/23
Y1 - 2009/7/23
N2 - Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field.
AB - Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field.
U2 - 10.1021/jm900321u
DO - 10.1021/jm900321u
M3 - Article
C2 - 19530698
AN - SCOPUS:67650760201
SN - 0022-2623
VL - 52
SP - 4538
EP - 4542
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 14
ER -