Abstract
Acylphosphonates behave as carbonyl components in Passerini reactions with isocyanides and carboxylic acids. Under saponification, the adducts undergo a phospha-Brook rearrangement to form α-amidophosphates. As acylphosphonates are quantitatively formed from carboxylic derivatives, this new reductive procedure allows acyl chlorides to react as aldehydes in a Passerini-type reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 1133-1136 |
| Number of pages | 4 |
| Journal | Synlett |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 5 May 2008 |
| Externally published | Yes |
Keywords
- Isocyanide
- Multicomponent reaction
- Passerini reaction
- Phosphonate