Isocyanide-based multicomponent reaction 'without' isocyanides

Laurent El Kaim; Laurence Grimaud; Aurélie Schiltz

doi:10.1055/s-0029-1217184

Isocyanide-based multicomponent reaction 'without' isocyanides

Laurent El Kaim
, Laurence Grimaud
, Aurélie Schiltz

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi-Smiles coupling.

Original language	English
Pages (from-to)	1401-1404
Number of pages	4
Journal	Synlett
Issue number	9
DOIs	https://doi.org/10.1055/s-0029-1217184
Publication status	Published - 1 Jan 2009
Externally published	Yes

Keywords

Alkylation
Isocyanides
Multicomponent reaction
Silver cyanide
Synthesis
Ugi-Smiles

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10.1055/s-0029-1217184

Cite this

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title = "Isocyanide-based multicomponent reaction 'without' isocyanides",

abstract = "We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi-Smiles coupling.",

keywords = "Alkylation, Isocyanides, Multicomponent reaction, Silver cyanide, Synthesis, Ugi-Smiles",

author = "\{El Kaim\}, Laurent and Laurence Grimaud and Aur{\'e}lie Schiltz",

year = "2009",

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doi = "10.1055/s-0029-1217184",

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journal = "Synlett",

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T1 - Isocyanide-based multicomponent reaction 'without' isocyanides

AU - El Kaim, Laurent

AU - Grimaud, Laurence

AU - Schiltz, Aurélie

PY - 2009/1/1

Y1 - 2009/1/1

N2 - We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi-Smiles coupling.

AB - We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a Ugi-Smiles coupling.

KW - Alkylation

KW - Isocyanides

KW - Multicomponent reaction

KW - Silver cyanide

KW - Synthesis

KW - Ugi-Smiles

UR - https://www.scopus.com/pages/publications/67649344311

U2 - 10.1055/s-0029-1217184

DO - 10.1055/s-0029-1217184

M3 - Article

AN - SCOPUS:67649344311

SN - 0936-5214

SP - 1401

EP - 1404

JO - Synlett

JF - Synlett

IS - 9

ER -

Isocyanide-based multicomponent reaction 'without' isocyanides

Abstract

Keywords

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