Isocyanide-based two- step three-component keteneimine formation

Didier Coffinier; Laurent El Kaim; Laurence Grimaud

doi:10.1021/ol9004432

Isocyanide-based two- step three-component keteneimine formation

Didier Coffinier
, Laurent El Kaim
, Laurence Grimaud

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow- type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.

Original language	English
Pages (from-to)	1824-1827
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/ol9004432
Publication status	Published - 16 Apr 2009
Externally published	Yes

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10.1021/ol9004432

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@article{c51a748ab634491eb8f8733cbe076393,

title = "Isocyanide-based two- step three-component keteneimine formation",

abstract = "The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow- type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.",

author = "Didier Coffinier and Kaim, \{Laurent El\} and Laurence Grimaud",

year = "2009",

month = apr,

day = "16",

doi = "10.1021/ol9004432",

language = "English",

volume = "11",

pages = "1824--1827",

journal = "Organic Letters",

issn = "1523-7060",

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TY - JOUR

T1 - Isocyanide-based two- step three-component keteneimine formation

AU - Coffinier, Didier

AU - Kaim, Laurent El

AU - Grimaud, Laurence

PY - 2009/4/16

Y1 - 2009/4/16

N2 - The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow- type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.

AB - The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow- type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.

UR - https://www.scopus.com/pages/publications/65249168883

U2 - 10.1021/ol9004432

DO - 10.1021/ol9004432

M3 - Article

C2 - 19320480

AN - SCOPUS:65249168883

SN - 1523-7060

VL - 11

SP - 1824

EP - 1827

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Isocyanide-based two- step three-component keteneimine formation

Abstract

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