Large-Scale Chromatin Rearrangements in Cancer

Kosuke Yamaguchi; Xiaoying Chen; Asami Oji; Ichiro Hiratani; Pierre Antoine Defossez

doi:10.3390/cancers14102384

Large-Scale Chromatin Rearrangements in Cancer

Kosuke Yamaguchi, Xiaoying Chen, Asami Oji, Ichiro Hiratani, Pierre Antoine Defossez

Research output: Contribution to journal › Review article › peer-review

Abstract

Epigenetic abnormalities are extremely widespread in cancer. Some of them are mere consequences of transformation, but some actively contribute to cancer initiation and progression; they provide powerful new biological markers, as well as new targets for therapies. In this review, we examine the recent literature and focus on one particular aspect of epigenome deregulation: large-scale chromatin changes, causing global changes of DNA methylation or histone modifications. After a brief overview of the one-dimension (1D) and three-dimension (3D) epigenome in healthy cells and of its homeostasis mechanisms, we use selected examples to describe how many different events (mutations, changes in metabolism, and infections) can cause profound changes to the epigenome and fuel cancer. We then present the consequences for therapies and briefly discuss the role of single-cell approaches for the future progress of the field.

Original language	English
Article number	2384
Journal	Cancers
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/cancers14102384
Publication status	Published - 1 May 2022
Externally published	Yes

Keywords

chromatin
epigenetics
genome organization
transformation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14102384

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title = "Large-Scale Chromatin Rearrangements in Cancer",

abstract = "Epigenetic abnormalities are extremely widespread in cancer. Some of them are mere consequences of transformation, but some actively contribute to cancer initiation and progression; they provide powerful new biological markers, as well as new targets for therapies. In this review, we examine the recent literature and focus on one particular aspect of epigenome deregulation: large-scale chromatin changes, causing global changes of DNA methylation or histone modifications. After a brief overview of the one-dimension (1D) and three-dimension (3D) epigenome in healthy cells and of its homeostasis mechanisms, we use selected examples to describe how many different events (mutations, changes in metabolism, and infections) can cause profound changes to the epigenome and fuel cancer. We then present the consequences for therapies and briefly discuss the role of single-cell approaches for the future progress of the field.",

keywords = "chromatin, epigenetics, genome organization, transformation",

author = "Kosuke Yamaguchi and Xiaoying Chen and Asami Oji and Ichiro Hiratani and Defossez, \{Pierre Antoine\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "1",

doi = "10.3390/cancers14102384",

language = "English",

volume = "14",

journal = "Cancers",

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TY - JOUR

T1 - Large-Scale Chromatin Rearrangements in Cancer

AU - Yamaguchi, Kosuke

AU - Chen, Xiaoying

AU - Oji, Asami

AU - Hiratani, Ichiro

AU - Defossez, Pierre Antoine

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Epigenetic abnormalities are extremely widespread in cancer. Some of them are mere consequences of transformation, but some actively contribute to cancer initiation and progression; they provide powerful new biological markers, as well as new targets for therapies. In this review, we examine the recent literature and focus on one particular aspect of epigenome deregulation: large-scale chromatin changes, causing global changes of DNA methylation or histone modifications. After a brief overview of the one-dimension (1D) and three-dimension (3D) epigenome in healthy cells and of its homeostasis mechanisms, we use selected examples to describe how many different events (mutations, changes in metabolism, and infections) can cause profound changes to the epigenome and fuel cancer. We then present the consequences for therapies and briefly discuss the role of single-cell approaches for the future progress of the field.

AB - Epigenetic abnormalities are extremely widespread in cancer. Some of them are mere consequences of transformation, but some actively contribute to cancer initiation and progression; they provide powerful new biological markers, as well as new targets for therapies. In this review, we examine the recent literature and focus on one particular aspect of epigenome deregulation: large-scale chromatin changes, causing global changes of DNA methylation or histone modifications. After a brief overview of the one-dimension (1D) and three-dimension (3D) epigenome in healthy cells and of its homeostasis mechanisms, we use selected examples to describe how many different events (mutations, changes in metabolism, and infections) can cause profound changes to the epigenome and fuel cancer. We then present the consequences for therapies and briefly discuss the role of single-cell approaches for the future progress of the field.

KW - chromatin

KW - epigenetics

KW - genome organization

KW - transformation

U2 - 10.3390/cancers14102384

DO - 10.3390/cancers14102384

M3 - Review article

AN - SCOPUS:85129872006

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 10

M1 - 2384

ER -

Large-Scale Chromatin Rearrangements in Cancer

Abstract

Keywords

UN SDGs

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