LES FACTEURS DE TRANSCRIPTION DU GROUPE PEA3 DANS LE CANCER MAMMAIRE

D. Monte; J. L. Baert; M. P. Laget; P. A. Defossez; L. Coutte; H. Pelczar; I. Angeli; F. Dewitte; D. Stehelin; Y. De Launoit

LES FACTEURS DE TRANSCRIPTION DU GROUPE PEA3 DANS LE CANCER MAMMAIRE

Translated title of the contribution: The PEA3 group of transcription factors in breast cancer

D. Monte
, J. L. Baert
, M. P. Laget
, P. A. Defossez
, L. Coutte
, H. Pelczar
, I. Angeli
, F. Dewitte
, D. Stehelin
, Y. De Launoit

Unité d'Oncologie Moléculaire
Institut Pasteur de Lille

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Prognosis factors such as mutated or amplified oncogenes are used in the treatment of breast cancer. We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. Moreover, we have shown that ER81, and to a lesser extent ERM and PEA3, are not expressed in the estrogen and/or progesterone receptor-positive mammary cancer cell lines, whereas they are expressed in the receptor negative ones. Our research interest is now focused on the role(s) of these oncogenes in the development and the regulation of breast tumors.

Translated title of the contribution	The PEA3 group of transcription factors in breast cancer
Original language	French
Pages (from-to)	547-551
Number of pages	5
Journal	Annales d'Endocrinologie
Volume	56
Issue number	5
Publication status	Published - 1 Dec 1995
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "LES FACTEURS DE TRANSCRIPTION DU GROUPE PEA3 DANS LE CANCER MAMMAIRE",

abstract = "Prognosis factors such as mutated or amplified oncogenes are used in the treatment of breast cancer. We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. Moreover, we have shown that ER81, and to a lesser extent ERM and PEA3, are not expressed in the estrogen and/or progesterone receptor-positive mammary cancer cell lines, whereas they are expressed in the receptor negative ones. Our research interest is now focused on the role(s) of these oncogenes in the development and the regulation of breast tumors.",

keywords = "PEA3 group, breast cancer",

author = "D. Monte and Baert, \{J. L.\} and Laget, \{M. P.\} and Defossez, \{P. A.\} and L. Coutte and H. Pelczar and I. Angeli and F. Dewitte and D. Stehelin and \{De Launoit\}, Y.",

year = "1995",

month = dec,

day = "1",

language = "Fran{\c c}ais",

volume = "56",

pages = "547--551",

journal = "Annales d'Endocrinologie",

issn = "0003-4266",

publisher = "Elsevier Masson s.r.l.",

number = "5",

}

TY - JOUR

T1 - LES FACTEURS DE TRANSCRIPTION DU GROUPE PEA3 DANS LE CANCER MAMMAIRE

AU - Monte, D.

AU - Baert, J. L.

AU - Laget, M. P.

AU - Defossez, P. A.

AU - Coutte, L.

AU - Pelczar, H.

AU - Angeli, I.

AU - Dewitte, F.

AU - Stehelin, D.

AU - De Launoit, Y.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Prognosis factors such as mutated or amplified oncogenes are used in the treatment of breast cancer. We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. Moreover, we have shown that ER81, and to a lesser extent ERM and PEA3, are not expressed in the estrogen and/or progesterone receptor-positive mammary cancer cell lines, whereas they are expressed in the receptor negative ones. Our research interest is now focused on the role(s) of these oncogenes in the development and the regulation of breast tumors.

AB - Prognosis factors such as mutated or amplified oncogenes are used in the treatment of breast cancer. We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. Moreover, we have shown that ER81, and to a lesser extent ERM and PEA3, are not expressed in the estrogen and/or progesterone receptor-positive mammary cancer cell lines, whereas they are expressed in the receptor negative ones. Our research interest is now focused on the role(s) of these oncogenes in the development and the regulation of breast tumors.

KW - PEA3 group

KW - breast cancer

M3 - Article

C2 - 8597501

AN - SCOPUS:0029563580

SN - 0003-4266

VL - 56

SP - 547

EP - 551

JO - Annales d'Endocrinologie

JF - Annales d'Endocrinologie

IS - 5

ER -

LES FACTEURS DE TRANSCRIPTION DU GROUPE PEA3 DANS LE CANCER MAMMAIRE

Abstract

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