Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

Qihao Wu; Bastien Nay; Min Yang; Yeke Ni; Hong Wang; Ligong Yao; Xuwen Li

doi:10.1016/j.apsb.2018.10.003

Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

Qihao Wu, Bastien Nay, Min Yang, Yeke Ni, Hong Wang, Ligong Yao, Xuwen Li

Research output: Contribution to journal › Review article › peer-review

Abstract

Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.

Original language	English
Pages (from-to)	237-257
Number of pages	21
Journal	Acta Pharmaceutica Sinica B
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.apsb.2018.10.003
Publication status	Published - 1 Mar 2019
Externally published	Yes

Keywords

Biological activity
Isolation
Marine drug leads
Marine natural products
Stelletta sponge
Total synthesis

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10.1016/j.apsb.2018.10.003

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title = "Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects",

abstract = "Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.",

keywords = "Biological activity, Isolation, Marine drug leads, Marine natural products, Stelletta sponge, Total synthesis",

author = "Qihao Wu and Bastien Nay and Min Yang and Yeke Ni and Hong Wang and Ligong Yao and Xuwen Li",

note = "Publisher Copyright: {\textcopyright} 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences",

year = "2019",

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doi = "10.1016/j.apsb.2018.10.003",

language = "English",

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journal = "Acta Pharmaceutica Sinica B",

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T1 - Marine sponges of the genus Stelletta as promising drug sources

T2 - chemical and biological aspects

AU - Wu, Qihao

AU - Nay, Bastien

AU - Yang, Min

AU - Ni, Yeke

AU - Wang, Hong

AU - Yao, Ligong

AU - Li, Xuwen

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.

AB - Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.

KW - Biological activity

KW - Isolation

KW - Marine drug leads

KW - Marine natural products

KW - Stelletta sponge

KW - Total synthesis

U2 - 10.1016/j.apsb.2018.10.003

DO - 10.1016/j.apsb.2018.10.003

M3 - Review article

AN - SCOPUS:85056807906

SN - 2211-3835

VL - 9

SP - 237

EP - 257

JO - Acta Pharmaceutica Sinica B

JF - Acta Pharmaceutica Sinica B

IS - 2

ER -

Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

Abstract

Keywords

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