Model description language (MDL): A standard for modeling and simulation

Mike K. Smith; Stuart L. Moodie; Roberto Bizzotto; Eric Blaudez; Elisa Borella; Letizia Carrara; Phylinda Chan; Marylore Chenel; Emmanuelle Comets; Ronald Gieschke; Kajsa Harling; Lutz Harnisch; Niklas Hartung; Andrew C. Hooker; Mats O. Karlsson; Richard Kaye; Charlotte Kloft; Natallia Kokash; Marc Lavielle; Giulia Lestini; Paolo Magni; Andrea Mari; France Mentré; Chris Muselle; Rikard Nordgren; Henrik B. Nyberg; Zinnia P. Parra-Guillén; Lorenzo Pasotti; Niels Rode-Kristensen; Maria L. Sardu; Gareth R. Smith; Maciej J. Swat; Nadia Terranova; Gunnar Yngman; Florent Yvon; Nick Holford

doi:10.1002/psp4.12222

Model description language (MDL): A standard for modeling and simulation

Mike K. Smith
, Stuart L. Moodie
, Roberto Bizzotto
, Eric Blaudez
, Elisa Borella
, Letizia Carrara
, Phylinda Chan
, Marylore Chenel
, Emmanuelle Comets
, Ronald Gieschke
, Kajsa Harling
, Lutz Harnisch
, Niklas Hartung
, Andrew C. Hooker
, Mats O. Karlsson
, Richard Kaye
, Charlotte Kloft
, Natallia Kokash
, Marc Lavielle
, Giulia Lestini

Paolo Magni, Andrea Mari, France Mentré, Chris Muselle, Rikard Nordgren, Henrik B. Nyberg, Zinnia P. Parra-Guillén, Lorenzo Pasotti, Niels Rode-Kristensen, Maria L. Sardu, Gareth R. Smith, Maciej J. Swat, Nadia Terranova, Gunnar Yngman, Florent Yvon, Nick Holford

Pfizer Limited, UK
Eight Pillars Ltd.
Ev-K2-CNR Committee
Lixoft
University of Pavia
Servier
INSERM U869
F. Hoffmann-La-Roche
Uppsala University
Free University of Berlin
Mango Solutions
University of Leiden
University College London
INRIA Institut National de Recherche en Informatique et en Automatique
Clínica Universidad de Navarra
Novo Nordisk A/S
Subsidiary of Merck KgaA
Cyprotex Discovery Limited
Addenbrookes Hospital
University of Auckland

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics.^1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.

Original language	English
Pages (from-to)	647-650
Number of pages	4
Journal	CPT: Pharmacometrics and Systems Pharmacology
Volume	6
Issue number	10
DOIs	https://doi.org/10.1002/psp4.12222
Publication status	Published - 1 Oct 2017
Externally published	Yes

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10.1002/psp4.12222

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Smith, M. K., Moodie, S. L., Bizzotto, R., Blaudez, E., Borella, E., Carrara, L., Chan, P., Chenel, M., Comets, E., Gieschke, R., Harling, K., Harnisch, L., Hartung, N., Hooker, A. C., Karlsson, M. O., Kaye, R., Kloft, C., Kokash, N., Lavielle, M., ... Holford, N. (2017). Model description language (MDL): A standard for modeling and simulation. CPT: Pharmacometrics and Systems Pharmacology, 6(10), 647-650. https://doi.org/10.1002/psp4.12222

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title = "Model description language (MDL): A standard for modeling and simulation",

abstract = "Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics.1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.",

author = "Smith, \{Mike K.\} and Moodie, \{Stuart L.\} and Roberto Bizzotto and Eric Blaudez and Elisa Borella and Letizia Carrara and Phylinda Chan and Marylore Chenel and Emmanuelle Comets and Ronald Gieschke and Kajsa Harling and Lutz Harnisch and Niklas Hartung and Hooker, \{Andrew C.\} and Karlsson, \{Mats O.\} and Richard Kaye and Charlotte Kloft and Natallia Kokash and Marc Lavielle and Giulia Lestini and Paolo Magni and Andrea Mari and France Mentr{\'e} and Chris Muselle and Rikard Nordgren and Nyberg, \{Henrik B.\} and Parra-Guill{\'e}n, \{Zinnia P.\} and Lorenzo Pasotti and Niels Rode-Kristensen and Sardu, \{Maria L.\} and Smith, \{Gareth R.\} and Swat, \{Maciej J.\} and Nadia Terranova and Gunnar Yngman and Florent Yvon and Nick Holford",

year = "2017",

month = oct,

day = "1",

doi = "10.1002/psp4.12222",

language = "English",

volume = "6",

pages = "647--650",

journal = "CPT: Pharmacometrics and Systems Pharmacology",

issn = "2163-8306",

publisher = "American Society for Clinical Pharmacology and Therapeutics",

number = "10",

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Smith, MK, Moodie, SL, Bizzotto, R, Blaudez, E, Borella, E, Carrara, L, Chan, P, Chenel, M, Comets, E, Gieschke, R, Harling, K, Harnisch, L, Hartung, N, Hooker, AC, Karlsson, MO, Kaye, R, Kloft, C, Kokash, N, Lavielle, M, Lestini, G, Magni, P, Mari, A, Mentré, F, Muselle, C, Nordgren, R, Nyberg, HB, Parra-Guillén, ZP, Pasotti, L, Rode-Kristensen, N, Sardu, ML, Smith, GR, Swat, MJ, Terranova, N, Yngman, G, Yvon, F & Holford, N 2017, 'Model description language (MDL): A standard for modeling and simulation', CPT: Pharmacometrics and Systems Pharmacology, vol. 6, no. 10, pp. 647-650. https://doi.org/10.1002/psp4.12222

TY - JOUR

T1 - Model description language (MDL)

T2 - A standard for modeling and simulation

AU - Smith, Mike K.

AU - Moodie, Stuart L.

AU - Bizzotto, Roberto

AU - Blaudez, Eric

AU - Borella, Elisa

AU - Carrara, Letizia

AU - Chan, Phylinda

AU - Chenel, Marylore

AU - Comets, Emmanuelle

AU - Gieschke, Ronald

AU - Harling, Kajsa

AU - Harnisch, Lutz

AU - Hartung, Niklas

AU - Hooker, Andrew C.

AU - Karlsson, Mats O.

AU - Kaye, Richard

AU - Kloft, Charlotte

AU - Kokash, Natallia

AU - Lavielle, Marc

AU - Lestini, Giulia

AU - Magni, Paolo

AU - Mari, Andrea

AU - Mentré, France

AU - Muselle, Chris

AU - Nordgren, Rikard

AU - Nyberg, Henrik B.

AU - Parra-Guillén, Zinnia P.

AU - Pasotti, Lorenzo

AU - Rode-Kristensen, Niels

AU - Sardu, Maria L.

AU - Smith, Gareth R.

AU - Swat, Maciej J.

AU - Terranova, Nadia

AU - Yngman, Gunnar

AU - Yvon, Florent

AU - Holford, Nick

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics.1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.

AB - Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics.1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.

U2 - 10.1002/psp4.12222

DO - 10.1002/psp4.12222

M3 - Review article

C2 - 28643440

AN - SCOPUS:85023162040

SN - 2163-8306

VL - 6

SP - 647

EP - 650

JO - CPT: Pharmacometrics and Systems Pharmacology

JF - CPT: Pharmacometrics and Systems Pharmacology

IS - 10

ER -

Model description language (MDL): A standard for modeling and simulation

Abstract

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