Molecular modeling of carbohydrates with no charges, no hydrogen bonds, and no atoms

  • Valeria Molinero
  • , William A. Goddard

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We review the M3B coarse grain model for glucans and their aqueous mixtures mat we show is able to describe the helical structures of oligo- and polysaccharides, experimental glass transition temperatures, and the dynamics of water in supercooled and glassy malto-oligosaccharide mixtures. M3B involves no electrostatic interactions, no hydrogen bonds, and no other directional nonbond interaction. Indeed M3B has no atoms, just three connected beads per monomer. M3B permits coarse grain simulations -7000 faster times than atomistics, yet provides at the end a mapping back to the full atomistic description.

Original languageEnglish
Title of host publicationNMR Spectroscopy and Computer Modeling of Carbohydrates
Subtitle of host publicationRecent Advances
EditorsJohannes Vliegenthart, Robert Woods
Pages271-284
Number of pages14
Publication statusPublished - 1 Dec 2006
Externally publishedYes

Publication series

NameACS Symposium Series
Volume930
ISSN (Print)0097-6156

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