Molecular recognition of quadruplex DNA by quinacridine derivatives

M. P. Teulade-Fichou; C. Hounsou; L. Guittat; J. L. Mergny; P. Alberti; C. Carrasco; C. Bailly; J. M. Lehn; W. D. Wilson

doi:10.1081/NCN-120023016

Molecular recognition of quadruplex DNA by quinacridine derivatives

M. P. Teulade-Fichou
, C. Hounsou
, L. Guittat
, J. L. Mergny
, P. Alberti
, C. Carrasco
, C. Bailly
, J. M. Lehn
, W. D. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.

Original language	English
Pages (from-to)	1483-1485
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120023016
Publication status	Published - 29 Sept 2003
Externally published	Yes

Keywords

Dibenzophenanthrolines
Molecular recognition
Quadruplex DNA

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10.1081/NCN-120023016

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abstract = "The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.",

keywords = "Dibenzophenanthrolines, Molecular recognition, Quadruplex DNA",

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AU - Teulade-Fichou, M. P.

AU - Hounsou, C.

AU - Guittat, L.

AU - Mergny, J. L.

AU - Alberti, P.

AU - Carrasco, C.

AU - Bailly, C.

AU - Lehn, J. M.

AU - Wilson, W. D.

PY - 2003/9/29

Y1 - 2003/9/29

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AB - The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.

KW - Dibenzophenanthrolines

KW - Molecular recognition

KW - Quadruplex DNA

U2 - 10.1081/NCN-120023016

DO - 10.1081/NCN-120023016

M3 - Article

C2 - 14565448

AN - SCOPUS:0141707926

SN - 1525-7770

VL - 22

SP - 1483

EP - 1485

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

Molecular recognition of quadruplex DNA by quinacridine derivatives

Abstract

Keywords

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