Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou; Aurore Guédin; Brian W. Skelton; Samir Amrane; Cameron W. Evans; Marck Norret; K. Swaminathan Iyer; Jean Louis Mergny; Nicole M. Smith

doi:10.1039/c8cc03945c

Multicarbazole scaffolds for selective G-quadruplex binding

Arnold Ou
, Aurore Guédin
, Brian W. Skelton
, Samir Amrane
, Cameron W. Evans
, Marck Norret
, K. Swaminathan Iyer
, Jean Louis Mergny
, Nicole M. Smith

School of Molecular Sciences
The University of Western Australia
Univ. Bordeaux
Centre for Microscopy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

Original language	English
Pages (from-to)	9647-9650
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	69
DOIs	https://doi.org/10.1039/c8cc03945c
Publication status	Published - 1 Jan 2018
Externally published	Yes

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10.1039/c8cc03945c

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title = "Multicarbazole scaffolds for selective G-quadruplex binding",

abstract = "Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.",

author = "Arnold Ou and Aurore Gu{\'e}din and Skelton, \{Brian W.\} and Samir Amrane and Evans, \{Cameron W.\} and Marck Norret and Iyer, \{K. Swaminathan\} and Mergny, \{Jean Louis\} and Smith, \{Nicole M.\}",

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doi = "10.1039/c8cc03945c",

language = "English",

volume = "54",

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T1 - Multicarbazole scaffolds for selective G-quadruplex binding

AU - Ou, Arnold

AU - Guédin, Aurore

AU - Skelton, Brian W.

AU - Amrane, Samir

AU - Evans, Cameron W.

AU - Norret, Marck

AU - Iyer, K. Swaminathan

AU - Mergny, Jean Louis

AU - Smith, Nicole M.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

AB - Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

U2 - 10.1039/c8cc03945c

DO - 10.1039/c8cc03945c

M3 - Article

C2 - 30101241

AN - SCOPUS:85052543812

SN - 1359-7345

VL - 54

SP - 9647

EP - 9650

JO - Chemical Communications

JF - Chemical Communications

IS - 69

ER -

Multicarbazole scaffolds for selective G-quadruplex binding

Abstract

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