Multicomponent synthesis of fused benzimidazolopiperazines

Laurent El Kaïm; Laurence Grimaud; Srinivas Reddy Purumandla

doi:10.1021/jo200397m

Multicomponent synthesis of fused benzimidazolopiperazines

Laurent El Kaïm
, Laurence Grimaud
, Srinivas Reddy Purumandla

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.

Original language	English
Pages (from-to)	4728-4733
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	76
Issue number	11
DOIs	https://doi.org/10.1021/jo200397m
Publication status	Published - 3 Jun 2011
Externally published	Yes

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title = "Multicomponent synthesis of fused benzimidazolopiperazines",

abstract = "We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.",

author = "\{El Ka{\"i}m\}, Laurent and Laurence Grimaud and \{Reddy Purumandla\}, Srinivas",

year = "2011",

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doi = "10.1021/jo200397m",

language = "English",

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journal = "Journal of Organic Chemistry",

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AU - El Kaïm, Laurent

AU - Grimaud, Laurence

AU - Reddy Purumandla, Srinivas

PY - 2011/6/3

Y1 - 2011/6/3

N2 - We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.

AB - We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.

U2 - 10.1021/jo200397m

DO - 10.1021/jo200397m

M3 - Article

C2 - 21486043

AN - SCOPUS:79957802475

SN - 0022-3263

VL - 76

SP - 4728

EP - 4733

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 11

ER -

Multicomponent synthesis of fused benzimidazolopiperazines

Abstract

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