Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

Jérémie Mathurin; Gaël Latour; Gervaise Mosser; Alexandre Dazzi; Marie Claire Schanne-Klein; Ariane Deniset-Besseau

doi:10.1039/d5an01298h

Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

Jérémie Mathurin
, Gaël Latour
, Gervaise Mosser
, Alexandre Dazzi
, Marie Claire Schanne-Klein
, Ariane Deniset-Besseau

UMR 8000 CNRS
Université Paris-Sud 11
Université Paris-Saclay
Sorbonne Université

Research output: Contribution to journal › Article › peer-review

Abstract

Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

Original language	English
Pages (from-to)	1881-1888
Number of pages	8
Journal	Analyst
Volume	151
Issue number	7
DOIs	https://doi.org/10.1039/d5an01298h
Publication status	Published - 30 Mar 2026

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abstract = "Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.",

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AU - Mathurin, Jérémie

AU - Latour, Gaël

AU - Mosser, Gervaise

AU - Dazzi, Alexandre

AU - Schanne-Klein, Marie Claire

AU - Deniset-Besseau, Ariane

PY - 2026/3/30

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N2 - Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

AB - Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.

UR - https://www.scopus.com/pages/publications/105032164772

U2 - 10.1039/d5an01298h

DO - 10.1039/d5an01298h

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VL - 151

SP - 1881

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JF - Analyst

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Multimodal AFM-IR nanospectroscopy and non-linear optical microscopy for detecting collagen matrix alterations

Abstract

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