New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

Thomas Colin; Laurent El Kaïm; Laetitia Gaultier; Laurence Grimaud; Laurent Gatay; Valérie Michaut

doi:10.1016/j.tetlet.2004.05.128

New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

Thomas Colin
, Laurent El Kaïm
, Laetitia Gaultier
, Laurence Grimaud
, Laurent Gatay
, Valérie Michaut

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane.

Original language	English
Pages (from-to)	5611-5613
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2004.05.128
Publication status	Published - 12 Jul 2004
Externally published	Yes

Keywords

Enamines
Isocyanide
Pyruvamide
Trifluoromethyl group

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10.1016/j.tetlet.2004.05.128

Cite this

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title = "New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides",

abstract = "Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane.",

keywords = "Enamines, Isocyanide, Pyruvamide, Trifluoromethyl group",

author = "Thomas Colin and \{El Ka{\"i}m\}, Laurent and Laetitia Gaultier and Laurence Grimaud and Laurent Gatay and Val{\'e}rie Michaut",

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doi = "10.1016/j.tetlet.2004.05.128",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

AU - Colin, Thomas

AU - El Kaïm, Laurent

AU - Gaultier, Laetitia

AU - Grimaud, Laurence

AU - Gatay, Laurent

AU - Michaut, Valérie

PY - 2004/7/12

Y1 - 2004/7/12

N2 - Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane.

AB - Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane.

KW - Enamines

KW - Isocyanide

KW - Pyruvamide

KW - Trifluoromethyl group

U2 - 10.1016/j.tetlet.2004.05.128

DO - 10.1016/j.tetlet.2004.05.128

M3 - Article

AN - SCOPUS:3042670427

SN - 0040-4039

VL - 45

SP - 5611

EP - 5613

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

Abstract

Keywords

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