New MCR-Heck-isomerization cascade toward indoles

Laurent El Kaim; Marion Gizzi; Laurence Grimaud

doi:10.1021/ol801217a

New MCR-Heck-isomerization cascade toward indoles

Laurent El Kaim
, Marion Gizzi
, Laurence Grimaud

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.

Original language	English
Pages (from-to)	3417-3419
Number of pages	3
Journal	Organic Letters
Volume	10
Issue number	16
DOIs	https://doi.org/10.1021/ol801217a
Publication status	Published - 1 Jan 2008
Externally published	Yes

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10.1021/ol801217a

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title = "New MCR-Heck-isomerization cascade toward indoles",

abstract = "(Chemical Equation Presented) The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.",

author = "\{El Kaim\}, Laurent and Marion Gizzi and Laurence Grimaud",

year = "2008",

month = jan,

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doi = "10.1021/ol801217a",

language = "English",

volume = "10",

pages = "3417--3419",

journal = "Organic Letters",

issn = "1523-7060",

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T1 - New MCR-Heck-isomerization cascade toward indoles

AU - El Kaim, Laurent

AU - Gizzi, Marion

AU - Grimaud, Laurence

PY - 2008/1/1

Y1 - 2008/1/1

N2 - (Chemical Equation Presented) The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.

AB - (Chemical Equation Presented) The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.

U2 - 10.1021/ol801217a

DO - 10.1021/ol801217a

M3 - Article

C2 - 18616343

AN - SCOPUS:54049090070

SN - 1523-7060

VL - 10

SP - 3417

EP - 3419

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

New MCR-Heck-isomerization cascade toward indoles

Abstract

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