New views on antidepressant action

Anne Baudry; Sophie Mouillet-Richard; Jean Marie Launay; Odile Kellermann

doi:10.1016/j.conb.2011.03.005

New views on antidepressant action

Anne Baudry
, Sophie Mouillet-Richard
, Jean Marie Launay
, Odile Kellermann

INSERM U869
F. Hoffmann-La-Roche
Hopital Lariboisière

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

The increasing incidence of depressive spectrum disorders worldwide, together with the failure of current medication to effectively treat a significant proportion of cases, calls for a better knowledge of the physiopathology of depression and of the therapeutic action of antidepressants. Recent research has unveiled an array of new mechanisms through which antidepressant drugs help restore neuronal plasticity and neurotransmission. In this review, we summarize the latest advances in the field, focusing on the effectors and molecular pathways that sustain the action of antidepressants. Grasping the overall brain response to antidepressants, with an integrated overview of the neurotransmitter systems, signaling cascades and neural circuits at play, should help to design more potent and selective therapies.

Original language	English
Pages (from-to)	858-865
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.conb.2011.03.005
Publication status	Published - 1 Dec 2011
Externally published	Yes

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10.1016/j.conb.2011.03.005

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title = "New views on antidepressant action",

abstract = "The increasing incidence of depressive spectrum disorders worldwide, together with the failure of current medication to effectively treat a significant proportion of cases, calls for a better knowledge of the physiopathology of depression and of the therapeutic action of antidepressants. Recent research has unveiled an array of new mechanisms through which antidepressant drugs help restore neuronal plasticity and neurotransmission. In this review, we summarize the latest advances in the field, focusing on the effectors and molecular pathways that sustain the action of antidepressants. Grasping the overall brain response to antidepressants, with an integrated overview of the neurotransmitter systems, signaling cascades and neural circuits at play, should help to design more potent and selective therapies.",

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AU - Baudry, Anne

AU - Mouillet-Richard, Sophie

AU - Launay, Jean Marie

AU - Kellermann, Odile

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N2 - The increasing incidence of depressive spectrum disorders worldwide, together with the failure of current medication to effectively treat a significant proportion of cases, calls for a better knowledge of the physiopathology of depression and of the therapeutic action of antidepressants. Recent research has unveiled an array of new mechanisms through which antidepressant drugs help restore neuronal plasticity and neurotransmission. In this review, we summarize the latest advances in the field, focusing on the effectors and molecular pathways that sustain the action of antidepressants. Grasping the overall brain response to antidepressants, with an integrated overview of the neurotransmitter systems, signaling cascades and neural circuits at play, should help to design more potent and selective therapies.

AB - The increasing incidence of depressive spectrum disorders worldwide, together with the failure of current medication to effectively treat a significant proportion of cases, calls for a better knowledge of the physiopathology of depression and of the therapeutic action of antidepressants. Recent research has unveiled an array of new mechanisms through which antidepressant drugs help restore neuronal plasticity and neurotransmission. In this review, we summarize the latest advances in the field, focusing on the effectors and molecular pathways that sustain the action of antidepressants. Grasping the overall brain response to antidepressants, with an integrated overview of the neurotransmitter systems, signaling cascades and neural circuits at play, should help to design more potent and selective therapies.

U2 - 10.1016/j.conb.2011.03.005

DO - 10.1016/j.conb.2011.03.005

M3 - Review article

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JO - Current Opinion in Neurobiology

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ER -

New views on antidepressant action

Abstract

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