Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Muriel Durandetti; Corinne Gosmini; Jacques Périchon

doi:10.1016/j.tet.2006.11.055

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Muriel Durandetti, Corinne Gosmini, Jacques Périchon

Institut de Chimie et des Matériaux de Paris Est, CNRS UPEC/UMR 7182

Research output: Contribution to journal › Article › peer-review

Abstract

Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.

Original language	English
Pages (from-to)	1146-1153
Number of pages	8
Journal	Tetrahedron
Volume	63
Issue number	5
DOIs	https://doi.org/10.1016/j.tet.2006.11.055
Publication status	Published - 29 Jan 2007
Externally published	Yes

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title = "Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters",

abstract = "Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.",

author = "Muriel Durandetti and Corinne Gosmini and Jacques P{\'e}richon",

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T2 - a simple method for the synthesis of α-arylesters and β-hydroxyesters

AU - Durandetti, Muriel

AU - Gosmini, Corinne

AU - Périchon, Jacques

PY - 2007/1/29

Y1 - 2007/1/29

N2 - Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.

AB - Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.

U2 - 10.1016/j.tet.2006.11.055

DO - 10.1016/j.tet.2006.11.055

M3 - Article

AN - SCOPUS:33845603147

SN - 0040-4020

VL - 63

SP - 1146

EP - 1153

JO - Tetrahedron

JF - Tetrahedron

IS - 5

ER -

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Abstract

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