One-pot synthesis of oxazoles using isocyanide surrogates

Laurent El Kaim; Laurence Grimaud; Aurélie Schiltz

doi:10.1016/j.tetlet.2009.07.001

One-pot synthesis of oxazoles using isocyanide surrogates

Laurent El Kaim
, Laurence Grimaud
, Aurélie Schiltz

Unité Chimie et Procédés

Research output: Contribution to journal › Article › peer-review

Abstract

We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the desired oxazoles in good yields.

Original language	English
Pages (from-to)	5235-5237
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	37
DOIs	https://doi.org/10.1016/j.tetlet.2009.07.001
Publication status	Published - 16 Sept 2009
Externally published	Yes

Keywords

Alkylation
Isocyanide
Multicomponent reaction
Oxazole
Silver cyanide

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10.1016/j.tetlet.2009.07.001

Cite this

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title = "One-pot synthesis of oxazoles using isocyanide surrogates",

abstract = "We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the desired oxazoles in good yields.",

keywords = "Alkylation, Isocyanide, Multicomponent reaction, Oxazole, Silver cyanide",

author = "Kaim, \{Laurent El\} and Laurence Grimaud and Aur{\'e}lie Schiltz",

year = "2009",

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doi = "10.1016/j.tetlet.2009.07.001",

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journal = "Tetrahedron Letters",

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T1 - One-pot synthesis of oxazoles using isocyanide surrogates

AU - Kaim, Laurent El

AU - Grimaud, Laurence

AU - Schiltz, Aurélie

PY - 2009/9/16

Y1 - 2009/9/16

N2 - We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the desired oxazoles in good yields.

AB - We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the desired oxazoles in good yields.

KW - Alkylation

KW - Isocyanide

KW - Multicomponent reaction

KW - Oxazole

KW - Silver cyanide

UR - https://www.scopus.com/pages/publications/67650892509

U2 - 10.1016/j.tetlet.2009.07.001

DO - 10.1016/j.tetlet.2009.07.001

M3 - Article

AN - SCOPUS:67650892509

SN - 0040-4039

VL - 50

SP - 5235

EP - 5237

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

One-pot synthesis of oxazoles using isocyanide surrogates

Abstract

Keywords

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