TY - JOUR
T1 - PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase
AU - Formstecher, Etienne
AU - Ramos, Joe W.
AU - Fauquet, Mireille
AU - Calderwood, David A.
AU - Hsieh, Jyh Cheng
AU - Canton, Brigitte
AU - Nguyen, Xuan Thao
AU - Barnier, Jean Vianney
AU - Camonis, Jacques
AU - Ginsberg, Mark H.
AU - Chneiweiss, Hervé
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The ERK 1/2 MAP kinase pathway controls cell growth and survival and modulates integrin function. Here, we report that PEA-15, a protein variably expressed in multiple cell types, blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their localization in the nucleus. PEA-15 contains a nuclear export sequence required for its capacity to anchor ERK in the cytoplasm. Genetic deletion of PEA-15 results in increased ERK nuclear localization with consequent increased cFos transcription and cell proliferation. Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase.
AB - The ERK 1/2 MAP kinase pathway controls cell growth and survival and modulates integrin function. Here, we report that PEA-15, a protein variably expressed in multiple cell types, blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their localization in the nucleus. PEA-15 contains a nuclear export sequence required for its capacity to anchor ERK in the cytoplasm. Genetic deletion of PEA-15 results in increased ERK nuclear localization with consequent increased cFos transcription and cell proliferation. Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase.
UR - https://www.scopus.com/pages/publications/18044405015
U2 - 10.1016/S1534-5807(01)00035-1
DO - 10.1016/S1534-5807(01)00035-1
M3 - Article
C2 - 11702783
AN - SCOPUS:18044405015
SN - 1534-5807
VL - 1
SP - 239
EP - 250
JO - Developmental Cell
JF - Developmental Cell
IS - 2
ER -