Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols

Laurent El Kaïm; Laurence Grimaud; Srinivas Reddy Purumandla

doi:10.1002/ejoc.201100939

Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols

Laurent El Kaïm
, Laurence Grimaud
, Srinivas Reddy Purumandla

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

Benzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates.

Original language	English
Pages (from-to)	6177-6180
Number of pages	4
Journal	European Journal of Organic Chemistry
Issue number	31
DOIs	https://doi.org/10.1002/ejoc.201100939
Publication status	Published - 1 Nov 2011
Externally published	Yes

Keywords

Cyclization
Fused-ring systems
Multicomponent reactions
Nitrogen heterocycles

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10.1002/ejoc.201100939

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title = "Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols",

abstract = "Benzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates.",

keywords = "Cyclization, Fused-ring systems, Multicomponent reactions, Nitrogen heterocycles",

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year = "2011",

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doi = "10.1002/ejoc.201100939",

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journal = "European Journal of Organic Chemistry",

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T2 - A one-pot four-component approach from nitrophenols

AU - El Kaïm, Laurent

AU - Grimaud, Laurence

AU - Purumandla, Srinivas Reddy

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Benzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates.

AB - Benzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates.

KW - Cyclization

KW - Fused-ring systems

KW - Multicomponent reactions

KW - Nitrogen heterocycles

UR - https://www.scopus.com/pages/publications/80054944069

U2 - 10.1002/ejoc.201100939

DO - 10.1002/ejoc.201100939

M3 - Article

AN - SCOPUS:80054944069

SN - 1434-193X

SP - 6177

EP - 6180

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 31

ER -

Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols

Abstract

Keywords

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