Abstract
The A3 coupling between N-ethylpiperazine and electron-rich aromatic aldehydes forms adducts that may be easily used as electrophiles towards electron-rich heterocycles such as indoles. The removal of the piperazine moiety is triggered by the addition of 1,2-dibromoethane. Overall, the reaction provides efficient access to alkynyl indoles and pyrroles.
| Original language | English |
|---|---|
| Article number | st-2016-d0042-l |
| Pages (from-to) | 1572-1576 |
| Number of pages | 5 |
| Journal | Synlett |
| Volume | 27 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2 Jun 2016 |
Keywords
- A3 reaction
- alkyne
- indoles
- piperazine