Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

Anne Cammas; Stephen M. Lewis; Stephan Vagner; Martin Holcik

doi:10.1016/j.bcp.2008.05.022

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

Anne Cammas
, Stephen M. Lewis
, Stephan Vagner
, Martin Holcik

INSERM U869
Institut Claudius Regaud
Université Paul Sabatier
Apoptosis Research Centre
University of Ottawa
Atlantic Cancer Research Institute

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression.

Original language	English
Pages (from-to)	1395-1403
Number of pages	9
Journal	Biochemical Pharmacology
Volume	76
Issue number	11
DOIs	https://doi.org/10.1016/j.bcp.2008.05.022
Publication status	Published - 1 Dec 2008
Externally published	Yes

Keywords

IRES
RNA binding protein
Signaling pathway
Splicing
Subcellular localization
Translation

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10.1016/j.bcp.2008.05.022

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abstract = "Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression.",

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AU - Holcik, Martin

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AB - Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression.

KW - IRES

KW - RNA binding protein

KW - Signaling pathway

KW - Splicing

KW - Subcellular localization

KW - Translation

U2 - 10.1016/j.bcp.2008.05.022

DO - 10.1016/j.bcp.2008.05.022

M3 - Article

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JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

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ER -

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

Abstract

Keywords

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