Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS

Natacha Bonneau; Isabelle Schmitz-Afonso; Alain Brunelle; David Touboul; Pierre Champy

doi:10.1016/j.toxicon.2016.03.015

Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS

Natacha Bonneau
, Isabelle Schmitz-Afonso
, Alain Brunelle
, David Touboul
, Pierre Champy

Research output: Contribution to journal › Article › peer-review

Abstract

The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed and validated. This method was applied to the quantitation of annonacin in Rat brain after intravenous (0.5 mg/kg) and oral (10 mg/kg, 100 mg/kg) administration.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Toxicon
Volume	118
DOIs	https://doi.org/10.1016/j.toxicon.2016.03.015
Publication status	Published - 1 Aug 2016
Externally published	Yes

Keywords

Acetogenin
Annonaceae
Annonacin
Distribution
Rat brain
UPLC-MS/MS

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10.1016/j.toxicon.2016.03.015

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title = "Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS",

abstract = "The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed and validated. This method was applied to the quantitation of annonacin in Rat brain after intravenous (0.5 mg/kg) and oral (10 mg/kg, 100 mg/kg) administration.",

keywords = "Acetogenin, Annonaceae, Annonacin, Distribution, Rat brain, UPLC-MS/MS",

author = "Natacha Bonneau and Isabelle Schmitz-Afonso and Alain Brunelle and David Touboul and Pierre Champy",

year = "2016",

month = aug,

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doi = "10.1016/j.toxicon.2016.03.015",

language = "English",

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T1 - Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS

AU - Bonneau, Natacha

AU - Schmitz-Afonso, Isabelle

AU - Brunelle, Alain

AU - Touboul, David

AU - Champy, Pierre

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed and validated. This method was applied to the quantitation of annonacin in Rat brain after intravenous (0.5 mg/kg) and oral (10 mg/kg, 100 mg/kg) administration.

AB - The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed and validated. This method was applied to the quantitation of annonacin in Rat brain after intravenous (0.5 mg/kg) and oral (10 mg/kg, 100 mg/kg) administration.

KW - Acetogenin

KW - Annonaceae

KW - Annonacin

KW - Distribution

KW - Rat brain

KW - UPLC-MS/MS

U2 - 10.1016/j.toxicon.2016.03.015

DO - 10.1016/j.toxicon.2016.03.015

M3 - Article

C2 - 27058514

AN - SCOPUS:84965071565

SN - 0041-0101

VL - 118

SP - 129

EP - 133

JO - Toxicon

JF - Toxicon

ER -

Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS

Abstract

Keywords

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