Recent Advances in Transition-Metal-Catalyzed Functionalization of 1-Thiosugars

Thioglycosides are valuable glycomimetic derivatives that have attracted much attention as mimetics of O-glycosides. Thioglycosides are among the most important glycomimetics reported to date due to their powerful activities. Owing to their importance, building up methods for their construction has drawn considerable attention. However, the classical methods of their synthesis presenting many shortcomings such as the use of harsh acidic media, and are generally limited in substrate scope. Therefore, metal-catalyzed coupling of thiosugars with halogenated electrophiles can be a superior and highly versatile approach to the sunthesis of thioglycosides. The central objective of this Focus Review is to highlight metal-catalyzed reactions for the creation of aromatic and heteroaromatic thioglycosides.