@inproceedings{4e74b2e82097460096d8e1668c8ac2f9,
title = "Red blood cell sickling in microfluidic droplets",
abstract = "We have developed a droplet-based microfluidic device to study the red blood cell sickling process associated with sickle cell anaemia. A primary trigger of red blood cell sickling is low oxygen partial pressure. By controlling the oxygen partial pressure of the incoming oil and aqueous phase, a microdroplet is subjected to a rapid change in oxygen concentration. Using a fluorescent oxygen probe, the oxygen change was shown to occur in less than a second and concentrated during and directly after droplet formation. The deoxygenation of droplets is shown to trigger red blood cell sickling in microdroplets.",
keywords = "Microdroplets, Oxygen, Red blood cells, Sickle cell anaemia, Single cell",
author = "Paul Abbyad and Baroud, \{Charles N.\} and Martin, \{Jean Louis\} and Tharaux, \{Pierre Louis\} and Antigoni Alexandrou",
year = "2009",
month = jan,
day = "1",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "493--495",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}