Abstract
New directions: The carboxylic acid functional group directs the ortho acylation of benzoic acids with carboxylic anhydrides in the presence of a rhodium catalyst (see scheme; cod=cyclo-1,5-octadiene). The acylation at the ortho position is complementary to the meta selectivity of Friedel-Crafts reactions. The resulting products can undergo protodecarboxylation to deliver an aryl ketone.
| Original language | English |
|---|---|
| Pages (from-to) | 6704-6708 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - 24 Jun 2013 |
| Externally published | Yes |
Keywords
- C-H functionalization
- acylation
- anhydrides
- ketones
- rhodium