Sandmeyer trifluoromethylation of arenediazonium tetrafluoroborates

Grégory Danoun; Bilguun Bayarmagnai; Matthias F. Grünberg; Lukas J. Gooßen

doi:10.1002/anie.201304276

Sandmeyer trifluoromethylation of arenediazonium tetrafluoroborates

Grégory Danoun
, Bilguun Bayarmagnai
, Matthias F. Grünberg
, Lukas J. Gooßen

University of Kaiserslautern

Research output: Contribution to journal › Article › peer-review

Abstract

Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me₃Si-CF₃ (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.

Original language	English
Pages (from-to)	7972-7975
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	31
DOIs	https://doi.org/10.1002/anie.201304276
Publication status	Published - 29 Jul 2013
Externally published	Yes

Keywords

Sandmeyer reaction
copper
diazonium salts
trifluoromethylation

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10.1002/anie.201304276

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abstract = "Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3Si-CF3 (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.",

keywords = "Sandmeyer reaction, copper, diazonium salts, trifluoromethylation",

author = "Gr{\'e}gory Danoun and Bilguun Bayarmagnai and Gr{\"u}nberg, \{Matthias F.\} and Goo{\ss}en, \{Lukas J.\}",

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doi = "10.1002/anie.201304276",

language = "English",

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AU - Danoun, Grégory

AU - Bayarmagnai, Bilguun

AU - Grünberg, Matthias F.

AU - Gooßen, Lukas J.

PY - 2013/7/29

Y1 - 2013/7/29

N2 - Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3Si-CF3 (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.

AB - Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3Si-CF3 (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.

KW - Sandmeyer reaction

KW - copper

KW - diazonium salts

KW - trifluoromethylation

U2 - 10.1002/anie.201304276

DO - 10.1002/anie.201304276

M3 - Article

C2 - 23832858

AN - SCOPUS:84880849768

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JF - Angewandte Chemie - International Edition

IS - 31

ER -

Sandmeyer trifluoromethylation of arenediazonium tetrafluoroborates

Abstract

Keywords

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