Sandmeyer trifluoromethylation

Grégory Danoun; Bilguun Bayarmagnai; Matthias F. Grünberg; Christian Matheis; Eugen Risto; Lukas J. Gooßen

doi:10.1055/s-0034-1378549

Sandmeyer trifluoromethylation

Grégory Danoun, Bilguun Bayarmagnai, Matthias F. Grünberg, Christian Matheis, Eugen Risto, Lukas J. Gooßen

University of Kaiserslautern

Research output: Contribution to journal › Article › peer-review

Abstract

A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF₃ through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.

Original language	English
Article number	ss-2014-z0399-psp
Pages (from-to)	2283-2286
Number of pages	4
Journal	Synthesis
Volume	46
Issue number	17
DOIs	https://doi.org/10.1055/s-0034-1378549
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

Sandmeyer reaction
anilines
copper
diazonium salts
trifluoromethylation

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10.1055/s-0034-1378549

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title = "Sandmeyer trifluoromethylation",

abstract = "A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.",

keywords = "Sandmeyer reaction, anilines, copper, diazonium salts, trifluoromethylation",

author = "Gr{\'e}gory Danoun and Bilguun Bayarmagnai and Gr{\"u}nberg, \{Matthias F.\} and Christian Matheis and Eugen Risto and Goo{\ss}en, \{Lukas J.\}",

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doi = "10.1055/s-0034-1378549",

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T1 - Sandmeyer trifluoromethylation

AU - Danoun, Grégory

AU - Bayarmagnai, Bilguun

AU - Grünberg, Matthias F.

AU - Matheis, Christian

AU - Risto, Eugen

AU - Gooßen, Lukas J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.

AB - A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.

KW - Sandmeyer reaction

KW - anilines

KW - copper

KW - diazonium salts

KW - trifluoromethylation

U2 - 10.1055/s-0034-1378549

DO - 10.1055/s-0034-1378549

M3 - Article

AN - SCOPUS:84906785276

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VL - 46

SP - 2283

EP - 2286

JO - Synthesis

JF - Synthesis

IS - 17

M1 - ss-2014-z0399-psp

ER -

Sandmeyer trifluoromethylation

Abstract

Keywords

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