Scaling limit of a discrete prion dynamics model

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Abstract

This paper investigates the connection between discrete and continuous models describing prion proliferation. The scaling parameters are interpreted on biological grounds and we establish rigorous convergence statements. We also discuss, based on the asymptotic analysis, relevant boundary conditions that can be used to complete the continuous model.

Original languageEnglish
Pages (from-to)839-865
Number of pages27
JournalCommunications in Mathematical Sciences
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Aggregation fragmentation equations
  • Asymptotic analysis
  • Polymerization process

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